Efficient Strategies for Calculating Blockwise Likelihoods Under the Coalescent.

@article{Lohse2016EfficientSF,
  title={Efficient Strategies for Calculating Blockwise Likelihoods Under the Coalescent.},
  author={K Lohse and Martin Chmelik and Simon H Martin and Nicholas H. Barton},
  journal={Genetics},
  year={2016},
  volume={202 2},
  pages={
          775-86
        }
}
The inference of demographic history from genome data is hindered by a lack of efficient computational approaches. In particular, it has proved difficult to exploit the information contained in the distribution of genealogies across the genome. We have previously shown that the generating function (GF) of genealogies can be used to analytically compute likelihoods of demographic models from configurations of mutations in short sequence blocks (Lohse et al. 2011). Although the GF has a simple… CONTINUE READING
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