Efficient MW-Assisted Synthesis, Spectroscopic Characterization, X-ray and Antioxidant Properties of Indazole Derivatives

@article{Polo2016EfficientMS,
  title={Efficient MW-Assisted Synthesis, Spectroscopic Characterization, X-ray and Antioxidant Properties of Indazole Derivatives},
  author={Efra{\'i}n Polo and J. Trilleras and Juan Ramos and A. Gald{\'a}mez and J. Quiroga and Margarita Guti{\'e}rrez},
  journal={Molecules},
  year={2016},
  volume={21}
}
A small series of tetrahydroindazoles was prepared, starting from 2-acetylcyclohexanone and different hydrazines using reflux and a focused microwave reactor. Microwave irradiation (MW) favored the formation of the desired products with improved yields and shortened reaction times. This is a simple and green method for the synthesis of substituted tetrahydroindazole derivatives. The in vitro antioxidant activity was evaluated using the DPPH and ABTS methods. In these assays, 2-(4-fluorophenyl… Expand
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