Efficient Iron‐Catalyzed Kumada Cross‐Coupling Reactions Utilizing Flow Technology under Low Catalyst Loadings

@article{Buono2016EfficientIK,
  title={Efficient Iron‐Catalyzed Kumada Cross‐Coupling Reactions Utilizing Flow Technology under Low Catalyst Loadings},
  author={F. Buono and Y. Zhang and Z. Tan and Andrew T. Brusoe and Bing-Shiou Yang and Jon C. Lorenz and R. Giovannini and J. Song and N. Yee and C. Senanayake},
  journal={European Journal of Organic Chemistry},
  year={2016},
  volume={2016},
  pages={2599-2602}
}
An efficient continuous flow iron-catalyzed Kumada cross-coupling was developed for the coupling of 2-chloropyrazine and various aryl Grignard reagents in presence of low catalyst loadings (0.5 mol-%). Compared to batch mode, the continuous flow approach overcomes the exothermicity which enabled longer catalyst lifetime, facilitated scale-up and significantly improved the yield. To the best of our knowledge, this is the first example of flow iron-catalyzed Kumada cross-coupling reactions which… Expand
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