Efficient Generation of Schwann Cells from Human Embryonic Stem Cell-Derived Neurospheres

@article{Ziegler2010EfficientGO,
  title={Efficient Generation of Schwann Cells from Human Embryonic Stem Cell-Derived Neurospheres},
  author={Lina Ziegler and Sergei Grigoryan and In Hong Yang and Nitish V. Thakor and Ronald S Goldstein},
  journal={Stem Cell Reviews and Reports},
  year={2010},
  volume={7},
  pages={394-403}
}
Schwann cells (SC), the glial cells of peripheral nerves, are involved in many diseases including Charcot Marie Tooth and neurofibromatosis, and play a pivotal role in peripheral nerve regeneration. Although it is possible to obtain human SC from nerve biopsies, they are difficult to maintain and expand in culture. Here we describe an efficient system for directing the differentiation of human embryonic stem cells (hESC) into cells with the morphological and molecular characteristics of SC… CONTINUE READING