Efficient Generation of Myostatin Gene Mutated Rabbit by CRISPR/Cas9

@inproceedings{Lv2016EfficientGO,
  title={Efficient Generation of Myostatin Gene Mutated Rabbit by CRISPR/Cas9},
  author={Qingyan Lv and Lin Yuan and Jichao Deng and Mao Chen and Yong Wang and Jian Guo Zeng and Zhanjun Li and Liangxue Lai},
  booktitle={Scientific reports},
  year={2016}
}
CRISPR/Cas9 has been widely used in generating site-specific genetically modified animal models. Myostatin (MSTN) is a negative regulator of muscle mass, related to muscle growth and differentiation. The knockout of MSTN with the desired phenotype of double muscle has been successfully generated in mice, goats, pigs and cattle, but not in rabbits. In this study, the MSTN knockout (KO) rabbits were generated by co-injection of Cas9 mRNA and sgRNA into zygotes. The typical phenotype of double… CONTINUE READING
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