Efficient Generation of Human Embryonic Stem Cell-Derived Corneal Endothelial Cells by Directed Differentiation

@inproceedings{Mccabe2015EfficientGO,
  title={Efficient Generation of Human Embryonic Stem Cell-Derived Corneal Endothelial Cells by Directed Differentiation},
  author={Kathryn L. Mccabe and Noelia J Kunzevitzky and Brian P. Chiswell and Xin Jie Xia and Jeffrey L. Goldberg and Robert Paul Lanza and Irina Kerkis},
  booktitle={PloS one},
  year={2015}
}
AIM To generate human embryonic stem cell derived corneal endothelial cells (hESC-CECs) for transplantation in patients with corneal endothelial dystrophies. MATERIALS AND METHODS Feeder-free hESC-CECs were generated by a directed differentiation protocol. hESC-CECs were characterized by morphology, expression of corneal endothelial markers, and microarray analysis of gene expression. RESULTS hESC-CECs were nearly identical morphologically to primary human corneal endothelial cells… CONTINUE READING

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