Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox Gene HEX

@inproceedings{Inamura2011EfficientGO,
  title={Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox Gene HEX},
  author={Mitsuru Inamura and Kenji Kawabata and Kazuo Takayama and Katsuhisa Tashiro and Fuminori Sakurai and Kazufumi Katayama and Masashi Toyoda and Hidenori Akutsu and Yoshitaka Miyagawa and Hajime Okita and Nobutaka Kiyokawa and Akihiro Umezawa and Takao Hayakawa and Miho Kusuda Furue and Hiroyuki Mizuguchi},
  booktitle={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2011}
}
Human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the potential to differentiate into all cell lineages, including hepatocytes, in vitro. Induced hepatocytes have a wide range of potential application in biomedical research, drug discovery, and the treatment of liver disease. However, the existing protocols for hepatic differentiation of PSCs are not very efficient. In this study, we developed an efficient method to induce hepatoblasts, which are progenitors of… CONTINUE READING