Efficient Direct Lineage Reprogramming of Fibroblasts into Induced Cardiomyocytes Using Nanotopographical Cues.

@article{Yoo2017EfficientDL,
  title={Efficient Direct Lineage Reprogramming of Fibroblasts into Induced Cardiomyocytes Using Nanotopographical Cues.},
  author={Junsang Yoo and Yujung Chang and Hongwon Kim and Soonbong Baek and Hwan Ju Choi and Gun-Jae Jeong and Jaein Shin and Hongnam Kim and Byung-Soo Kim and Jongpil Kim},
  journal={Journal of biomedical nanotechnology},
  year={2017},
  volume={13 3},
  pages={269-79}
}
Induced cardiomyocytes (iCMs) generated via direct lineage reprogramming offer a novel therapeutic target for the study and treatment of cardiac diseases. However, the efficiency of iCM generation is significantly low for therapeutic applications. Here, we show an efficient direct conversion of somatic fibroblasts into iCMs using nanotopographic cues… CONTINUE READING