Efficient Dielectrophoretic Patterning of Embryonic Stem Cells in Energy Landscapes Defined by Hydrogel Geometries

@inproceedings{Tsutsui2010EfficientDP,
  title={Efficient Dielectrophoretic Patterning of Embryonic Stem Cells in Energy Landscapes Defined by Hydrogel Geometries},
  author={Hideaki Tsutsui and Edmond Yu and Sabrina Marquina and Bahram Valamehr and Ieong Wong and Hong Wu and Chih-Ming Ho},
  booktitle={Annals of Biomedical Engineering},
  year={2010}
}
In this study, we have developed an integrated microfluidic platform for actively patterning mammalian cells, where poly(ethylene glycol) (PEG) hydrogels play two important roles as a non-fouling layer and a dielectric structure. The developed system has an embedded array of PEG microwells fabricated on a planar indium tin oxide (ITO) electrode. Due to its dielectric properties, the PEG microwells define electrical energy landscapes, effectively forming positive dielectrophoresis (DEP) traps in… CONTINUE READING
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