Efficient Delivery of Human Cytomegalovirus T Cell Antigens by Attenuated Sendai Virus Vectors.

@article{Kiener2018EfficientDO,
  title={Efficient Delivery of Human Cytomegalovirus T Cell Antigens by Attenuated Sendai Virus Vectors.},
  author={Richard Kiener and Markus Fleischmann and Marian Alexander Wiegand and Niels A W Lemmermann and Christiane Schwegler and Christine Kaufmann and Ang{\'e}lique Renzaho and Simone Thomas and Eva Felder and H. H. Niller and Benedikt Asbach and Ralf Wagner},
  journal={Journal of virology},
  year={2018},
  volume={92 15}
}
Human cytomegalovirus (HCMV) represents a major cause of clinical complications during pregnancy as well as immunosuppression, and the licensing of a protective HCMV vaccine remains an unmet global need. Here, we designed and validated novel Sendai virus (SeV) vectors delivering the T cell immunogens IE-1 and pp65. To enhance vector safety, we used a replication-deficient strain (rdSeV) that infects target cells in a nonproductive manner while retaining viral gene expression. In this study, we… CONTINUE READING
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