Efficient Access to Bicyclo[4.3.0]nonanes: Copper-Catalyzed Asymmetric Silylative Cyclization of Cyclohexadienone-Tethered Allenes.

@article{He2015EfficientAT,
  title={Efficient Access to Bicyclo[4.3.0]nonanes: Copper-Catalyzed Asymmetric Silylative Cyclization of Cyclohexadienone-Tethered Allenes.},
  author={Zhi-Tao He and Xiao-Qi Tang and Li-Bo Xie and Mian Cheng and Ping Tian and Guo-qiang Lin},
  journal={Angewandte Chemie},
  year={2015},
  volume={54 49},
  pages={14815-8}
}
The creation of three consecutive chiral carbon centers in one step is achieved using Cu-catalyzed asymmetric silylative cyclization of cyclohexadienone-tethered allenes. Through regioselective β-silylation of the allene and subsequent enantioselective 1,4-addition to cyclohexadienone, this tandem reaction could afford cis-hydrobenzofuran, cis-hydroindole… CONTINUE READING