Efficient, interactive, and three-dimensional segmentation of cell nuclei in thick tissue sections.

@article{Lockett1998EfficientIA,
  title={Efficient, interactive, and three-dimensional segmentation of cell nuclei in thick tissue sections.},
  author={Stephen J. Lockett and Damir Sudar and C T Thompson and Daniel Pinkel and Joe W. Gray},
  journal={Cytometry},
  year={1998},
  volume={31 4},
  pages={
          275-86
        }
}
Segmentation of intact cell nuclei in three-dimensional (3D) images of thick tissue sections is an important basic capability necessary for many biological research studies. Because automatic algorithms do not correctly segment all nuclei in tissue sections, interactive algorithms may be preferable for some applications. Existing interactive segmentation algorithms require the analyst to draw a border around the nucleus under consideration in all successive two-dimensional (2D) planes of the 3D… 

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