Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions

@inproceedings{Wilgenburg2013EfficientLT,
  title={Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions},
  author={Bonnie van Wilgenburg and Cathy Browne and Jane Vowles and Sally A Cowley},
  booktitle={PloS one},
  year={2013}
}
Human macrophages are specialised hosts for HIV-1, dengue virus, Leishmania and Mycobacterium tuberculosis. Yet macrophage research is hampered by lack of appropriate cell models for modelling infection by these human pathogens, because available myeloid cell lines are, by definition, not terminally differentiated like tissue macrophages. We describe here a method for deriving monocytes and macrophages from human Pluripotent Stem Cells which improves on previously published protocols in that it… CONTINUE READING
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Macrophages from human Pluripotent Stem Cells

  • SA Cowley, KR Karlsson, B van Wilgenburg, G Carter, C Browne
  • In: Takahashi R HK,
  • 2012
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