Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay.

Abstract

In mammalian cells, nonsense-mediated mRNA decay (NMD) is a consequence of nonsense codon recognition during a pioneer round of translation. This round can occur largely before or largely after the release of newly synthesized mRNA from nuclei, depending on the mRNA, and likely utilizes cytoplasmic ribosomes. We show that increasing the cellular… (More)
DOI: 10.1016/j.molcel.2007.12.009

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Cite this paper

@article{Sato2008EfficiencyOT, title={Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay.}, author={Hanae Sato and Nao Hosoda and Lynne E Maquat}, journal={Molecular cell}, year={2008}, volume={29 2}, pages={255-62} }