Efficiency of P-glycoprotein-mediated exclusion of rhodamine dyes from multidrug-resistant cells is determined by their passive transmembrane movement rate.

@article{Eytan1997EfficiencyOP,
  title={Efficiency of P-glycoprotein-mediated exclusion of rhodamine dyes from multidrug-resistant cells is determined by their passive transmembrane movement rate.},
  author={Gera D Eytan and Ronit Regev and Gal Oren and C D Hurwitz and Yehuda G Assaraf},
  journal={European journal of biochemistry},
  year={1997},
  volume={248 1},
  pages={104-12}
}
The aim of the present study was to examine the relationship between the rate of the passive transmembrane movement of multidrug resistance (MDR)-type substrates and the ability of P-glycoprotein to extrude them from MDR cells. For this purpose, seven rhodamine dyes were examined for their P-glycoprotein-mediated exclusion from MDR cells, their localization in wild-type drug-sensitive cells, their capacity to stimulate the ATPase activity of P-glycoprotein reconstituted in proteoliposomes, and… CONTINUE READING

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