Efficiency of Chitosan-Coated PLGA Nanocarriers for Cellular Delivery of siRNA and CRISPR/Cas9 Complex

  title={Efficiency of Chitosan-Coated PLGA Nanocarriers for Cellular Delivery of siRNA and CRISPR/Cas9 Complex},
  author={Ashu Vipin Srivastav and Kritika Gupta and Debojyoti Chakraborty and Prajakta P Dandekar and Ratnesh D Jain},
  journal={Journal of Pharmaceutical Innovation},
Purpose Most studies based on siRNA or CRISPR/Cas9 systems rely on viral vectors for their transfection. However, these viral vectors are immunogenic, which limits their application in gene therapy. Thus, identification of novel vectors with higher safety and improved targeting is desirable. Hence, we have explored the potential of biodegradable, chitosan coated PLGA nanocarriers for intracellular delivery of CRISPR/Cas9, and siRNA. In this investigation, we have compared the efficiency of… 

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  • H. RagelleR. Riva V. Préat
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Delivery strategies of the CRISPR‐Cas9 gene‐editing system for therapeutic applications