Efficiency of Chitosan-Coated PLGA Nanocarriers for Cellular Delivery of siRNA and CRISPR/Cas9 Complex

@article{Srivastav2020EfficiencyOC,
  title={Efficiency of Chitosan-Coated PLGA Nanocarriers for Cellular Delivery of siRNA and CRISPR/Cas9 Complex},
  author={Ashu Srivastav and Kritika Gupta and Debojyoti Chakraborty and Prajakta P Dandekar and Ratnesh D Jain},
  journal={Journal of Pharmaceutical Innovation},
  year={2020},
  volume={17},
  pages={180-193}
}
Purpose Most studies based on siRNA or CRISPR/Cas9 systems rely on viral vectors for their transfection. However, these viral vectors are immunogenic, which limits their application in gene therapy. Thus, identification of novel vectors with higher safety and improved targeting is desirable. Hence, we have explored the potential of biodegradable, chitosan coated PLGA nanocarriers for intracellular delivery of CRISPR/Cas9, and siRNA. In this investigation, we have compared the efficiency of… 
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3 Citations

A Short Review on Recent Applications of Chitosan Biopolymer in Gene and Drug Delivery

The amenability of structural modification, non-toxicity and high biodegradability of chitosan derivatives can make them prospective carriers for controlled drug delivery in future.

Advances in Chitosan-Based CRISPR/Cas9 Delivery Systems

A critical analysis of the different approaches for the generation of chitosan-based CRISPR/Cas9 delivery systems and suggestions for future developments are offered.

CRISPR-Cas9 based non-viral approaches in nanoparticle elicited therapeutic delivery

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