Efficiency gains in tracer identification for nuclear imaging: can in vivo LC-MS/MS evaluation of small molecules screen for successful PET tracers?

@article{Joshi2014EfficiencyGI,
  title={Efficiency gains in tracer identification for nuclear imaging: can in vivo LC-MS/MS evaluation of small molecules screen for successful PET tracers?},
  author={Elizabeth M Joshi and Anne B. Need and John M. Schaus and Zhaogen Chen and Dana Rae Benesh and Charles Mitch and Stuart Morton and Thomas J. Raub and Lee Phebus and Vanessa N. Barth},
  journal={ACS chemical neuroscience},
  year={2014},
  volume={5 12},
  pages={
          1154-63
        }
}
Positron emission tomography (PET) imaging has become a useful noninvasive technique to explore molecular biology within living systems; however, the utility of this method is limited by the availability of suitable radiotracers to probe specific targets and disease biology. Methods to identify potential areas of improvement in the ability to predict small molecule performance as tracers prior to radiolabeling would speed the discovery of novel tracers. In this retrospective analysis, we… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Similar Papers

Loading similar papers…