Efficiency and mechanism of antigen-specific CD8+ T-cell activation using synthetic long peptides.

@article{Zandvliet2012EfficiencyAM,
  title={Efficiency and mechanism of antigen-specific CD8+ T-cell activation using synthetic long peptides.},
  author={Maarten Laurens Zandvliet and Michel G. D. Kester and Ellis van Liempt and Arnoud H. de Ru and Peter A. van Veelen and Marieke Griffioen and Henk-Jan Guchelaar and J H Frederik Falkenburg and Pauline Meij},
  journal={Journal of immunotherapy},
  year={2012},
  volume={35 2},
  pages={
          142-53
        }
}
Synthetic long peptides that contain immunogenic T-cell epitopes have been used to induce activation of antigen-specific CD8 T cells in vitro for immune monitoring or adoptive transfer, or in vivo after peptide vaccination. However, the efficiency and mechanisms of presentation of exogenous long peptides in human leukocyte antigen (HLA) class I remain to be elucidated. In this study, we demonstrated that the efficiency of antigen-specific CD8 T-cell activation using extended peptide variants of… CONTINUE READING

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