Efficiency and fidelity of human DNA polymerases λ and β during gap-filling DNA synthesis.

Abstract

The base excision repair (BER) pathway coordinates the replacement of 1-10 nucleotides at sites of single-base lesions. This process generates DNA substrates with various gap sizes which can alter the catalytic efficiency and fidelity of a DNA polymerase during gap-filling DNA synthesis. Here, we quantitatively determined the substrate specificity and base… (More)
DOI: 10.1016/j.dnarep.2010.09.005

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