Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine.

@article{Hammer2013EfficacyTO,
  title={Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine.},
  author={S. Hammer and M. Sobieszczyk and H. Janes and S. Karuna and M. Mulligan and D. Grove and B. Koblin and S. Buchbinder and M. Keefer and G. Tomaras and N. Frahm and J. Hural and Chuka Anude and B. Graham and M. Enama and E. Adams and E. Dejesus and R. Novak and I. Frank and Carter Bentley and Shelly Ramirez and Rong Fu and R. Koup and J. Mascola and G. Nabel and D. Montefiori and J. Kublin and M. McElrath and L. Corey and P. Gilbert},
  journal={The New England journal of medicine},
  year={2013},
  volume={369 22},
  pages={
          2083-92
        }
}
BACKGROUND A safe and effective vaccine for the prevention of human immunodeficiency virus type 1 (HIV-1) infection is a global priority. We tested the efficacy of a DNA prime-recombinant adenovirus type 5 boost (DNA/rAd5) vaccine regimen in persons at increased risk for HIV-1 infection in the United States. METHODS At 21 sites, we randomly assigned 2504 men or transgender women who have sex with men to receive the DNA/rAd5 vaccine (1253 participants) or placebo (1251 participants). We… Expand
454 Citations

Paper Mentions

Interventional Clinical Trial
The purpose of this study is to determine the safety and efficacy of a VRC DNA/rAd5 vaccine regimen in healthy, circumcised men and male-to-female (MTF) transgender persons who have sex… Expand
ConditionsHIV Infections
InterventionBiological
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References

SHOWING 1-10 OF 38 REFERENCES
Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine.
  • 210
  • PDF
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand.
  • 2,748
  • PDF
...
1
2
3
4
...