Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children

@article{Vorilhon2018EfficacyOV,
  title={Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children},
  author={Philippe Vorilhon and Bastien Arpajou and H{\'e}l{\`e}ne Vaillant Roussel and {\'E}tienne Merlin and Bruno Pereira and Aur{\'e}lie Cabaillot},
  journal={European Journal of Clinical Pharmacology},
  year={2018},
  volume={75},
  pages={303-311}
}
PurposeUpper respiratory tract infection (URTI) is a common infection in children, generally caused by viral respiratory infection. Vitamin C is currently proposed as prophylaxis for URTI. The purpose of this study was to assess the effectiveness of vitamin C administration in children for the prevention and reduced duration of URTI through a systematic literature review.MethodsReview of the literature conducted between October 2017 and January 2018 in the main medical databases (CENTRAL… 

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References

SHOWING 1-10 OF 42 REFERENCES

The effect of vitamin C on upper respiratory infections in adolescent swimmers: a randomized trial

TLDR
It is found that vitamin C decreased the duration and severity of respiratory infections in male swimmers, but not in females, and this finding warrants further research.

Probiotics for preventing acute upper respiratory tract infections

TLDR
It is found that probiotics were better than placebo in reducing the number of participants experiencing episodes of acute URTI, the mean duration of an episode of acute United States upper respiratory tract infections, antibiotic use and cold-related school absence and the quality of the evidence was low or very low.

Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study

TLDR
Supplementation with a probiotic/vitamin C combination may be beneficial in the prevention and management of URTIs.

Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in preventing respiratory tract infections in children: a randomized, double-blind, placebo-controlled, multicenter study.

TLDR
A preventive effect of a product containing echinacea, propolis, and vitamin C on the incidence of respiratory tract infections in children during a 12-week winter period was observed.

Vitamin C prophylaxis in a boarding school.

Abstract A double-blind study to evaluate vitamin C supplements for respiratory-Infection prophylaxis was conducted among 641 children at a Navajo boarding school over a 14-week period. Supplements

Vitamin C as a preventive medicine against common colds in children.

TLDR
Results seemed to indicate that the duration and severity of the cold were reduced while, on the other hand, the incidence remained unaltered or indeed increased, like previously published studies on children.

Vitamin C and acute illness in Navajo school children.

TLDR
Vitamin C does not seem to be an effective prophylactic or therapeutic agent for upper respiratory illness.

VALOR PROFILÁCTICO DE LA VITAMINA C EN INFECCIONES RESPIRATORIAS AGUDAS DEL ESCOLAR

TLDR
Results suggest that Vitamin C does not prevent ARI in children but does diminish its duration, and in general children treated with Vitamin C had 37% less days of morbility caused by ARI than the placebo group.

Antibiotics for the common cold and acute purulent rhinitis.

TLDR
There is no evidence of benefit from antibiotics for the common cold or for persisting acute purulent rhinitis in children or adults, and there is evidence that antibiotics cause significant adverse effects in adults when given for theCommon cold and in all ages whengiven for acute purulencerhinitis.