Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children

  title={Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children},
  author={Philippe Vorilhon and Bastien Arpajou and H{\'e}l{\`e}ne Vaillant Roussel and {\'E}tienne Merlin and Bruno Pereira and Aur{\'e}lie Cabaillot},
  journal={European Journal of Clinical Pharmacology},
PurposeUpper respiratory tract infection (URTI) is a common infection in children, generally caused by viral respiratory infection. Vitamin C is currently proposed as prophylaxis for URTI. The purpose of this study was to assess the effectiveness of vitamin C administration in children for the prevention and reduced duration of URTI through a systematic literature review.MethodsReview of the literature conducted between October 2017 and January 2018 in the main medical databases (CENTRAL… 

Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: randomised controlled trial.

It is indicated that six months daily supplementation with the Lab4 probiotic and vitamin C combination reduces the incidence of coughing, absenteeism and antibiotic usage in 3 to 10 year old children.

Vitamin C intake and multiple health outcomes: an umbrella review of systematic reviews and meta-analyses

Dose–response analysis showed that vitamin C intake was associated with reduced risk of all-cause mortality, cardiovascular disease (CVD), oesophageal cancer, gastric cancer, cervical cancer and lung cancer with an increment of 50–100 mg per day.

The Role of Vitamin C as Adjuvant Therapy in COVID-19

VC can significantly improve clinical symptoms in patients affected with COVID-19; however, it had no impact on mortality and the need for mechanical ventilation.

Commentary: The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19

Cerullo stated “According to Pauling, a daily vitamin C intake of 1,000 mg can reduce the incidence of colds by about 45% (3, 4). However, other clinical studies with similar aims failed to

Combined drugs in the treatment of acute respiratory viral infections: a review of research results

  • V. Tsvetkov
  • Medicine
    Meditsinskiy sovet = Medical Council
  • 2021
The results of numerous comparative and placebo-controlled trials showed that the use of fixed-dose combinations of paracetamol, pheniramine maleate, phenylephrine hydrochloride and ascorbic acid in the ARVI therapy was pathogenetically justified, safe, and effective in relieving symptoms.

Overview of the possible role of vitamin C in management of COVID-19

Given the fact that vitamin C is cheap, available and safe drug with beneficial effects in management of viral infections and critically ill patients reported in previous clinical trials, it is sensible to add it to COVID-19 management protocol particularly if the current ongoing clinical trials testing the effect of vitamin C show positive results.

Assessment of Upper Respiratory Tract Diseases Empiric Management in community pharmacies of Sulaymaniyah City, Kurdistan, Iraq

There is a need for a larger survey on the skill of community pharmacy practitioners on the management of URT diseases, and, common cold and pharyngitis were the most common types.

Oral vitamin C supplements to prevent and treat acute upper respiratory tract infections

This is a protocol for a Cochrane Review (Intervention) to assess the effectiveness of oral vitamin C supplements to prevent and treat acute upper respiratory tract infections in adults and children.

Non-antibiotic medication use in an Indonesian community cohort 0–18 months of age

A large number of children were exposed to at least one medication during their early life, including those where evidence of efficacy and safety in a pediatric population is lacking, which supports the need for further research on pediatric drug therapy to improve the appropriate use of medication in this population.

The Immunologic Role of Vitamins C and D and Their Potential in the Management of COVID-19 Infections

This review will investigate the effects of vitamins C and D on COVID-19 infection to determine their benefits in the management of patients infected by the Severe Acute Respiratory Syndrome Coronavirus 2.



The effect of vitamin C on upper respiratory infections in adolescent swimmers: a randomized trial

It is found that vitamin C decreased the duration and severity of respiratory infections in male swimmers, but not in females, and this finding warrants further research.

Probiotics for preventing acute upper respiratory tract infections

It is found that probiotics were better than placebo in reducing the number of participants experiencing episodes of acute URTI, the mean duration of an episode of acute United States upper respiratory tract infections, antibiotic use and cold-related school absence and the quality of the evidence was low or very low.

Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study

Supplementation with a probiotic/vitamin C combination may be beneficial in the prevention and management of URTIs.

Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in preventing respiratory tract infections in children: a randomized, double-blind, placebo-controlled, multicenter study.

A preventive effect of a product containing echinacea, propolis, and vitamin C on the incidence of respiratory tract infections in children during a 12-week winter period was observed.

Vitamin C prophylaxis in a boarding school.

Abstract A double-blind study to evaluate vitamin C supplements for respiratory-Infection prophylaxis was conducted among 641 children at a Navajo boarding school over a 14-week period. Supplements

Vitamin C as a preventive medicine against common colds in children.

Results seemed to indicate that the duration and severity of the cold were reduced while, on the other hand, the incidence remained unaltered or indeed increased, like previously published studies on children.

Vitamin C and acute illness in Navajo school children.

Vitamin C does not seem to be an effective prophylactic or therapeutic agent for upper respiratory illness.


Results suggest that Vitamin C does not prevent ARI in children but does diminish its duration, and in general children treated with Vitamin C had 37% less days of morbility caused by ARI than the placebo group.

Antibiotics for the common cold and acute purulent rhinitis.

There is no evidence of benefit from antibiotics for the common cold or for persisting acute purulent rhinitis in children or adults, and there is evidence that antibiotics cause significant adverse effects in adults when given for theCommon cold and in all ages whengiven for acute purulencerhinitis.