Efficacy of vaccination with live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine.

@article{Belshe2000EfficacyOV,
  title={Efficacy of vaccination with live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine.},
  author={Robert B. Belshe and William C. Gruber and Paul M. Mendelman and Iksung Cho and Keith S. Reisinger and Stanley L. Block and Janet Wittes and Dominick A Iacuzio and Pedro A Piedra and John T Treanor and James King and Karen L. Kotloff and David I. Bernstein and Frederick G. Hayden and Ken Zangwill and Lihan K Yan and Mark Wolff},
  journal={The Journal of pediatrics},
  year={2000},
  volume={136 2},
  pages={168-75}
}
OBJECTIVE To determine the safety, immunogenicity, and efficacy of revaccination of children with live attenuated influenza vaccine. STUDY DESIGN A 2-year multicenter, double-blind, placebo-controlled, efficacy field trial of live attenuated, cold-adapted trivalent influenza vaccine administered by nasal spray to children. This report summarizes year 2 results, a year in which the epidemic strain of influenza A/Sydney was not well matched to the vaccine strains. Each year, vaccine strains… CONTINUE READING
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