Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial

@article{Berman2004EfficacyOT,
  title={Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial},
  author={Jonathan S. Berman and C M Symonds and Rolfe Birch},
  journal={Pain},
  year={2004},
  volume={112},
  pages={299-306}
}

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References

SHOWING 1-10 OF 48 REFERENCES
Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies
TLDR
A total of 34 ‘N of 1’ studies were undertaken using this novel therapy for patients with chronic, mainly neuropathic, pain and associated symptoms to explore efficacy, tolerability, safety and dosages of CBME.
A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms
TLDR
Cannabis medicinal extracts can improve neurogenic symptoms unresponsive to standard treatments, and unwanted effects are predictable and generally well tolerated.
Pain relief with oral cannabinoids in familial Mediterranean fever
TLDR
This is the first United Kingdom report of the controlled use of a standardised pharmaceutical preparation of cannabinoids in capsular form and a highly significant reduction in additional analgesic requirements was achieved.
Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review
TLDR
Cannabinoids are no more effective than codeine in controlling pain and have depressant effects on the central nervous system that limit their use, and in acute postoperative pain they should not be used.
The synthetic cannabinoid WIN55,212‐2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain
TLDR
The data indicate that cannabinoids may have therapeutic potential in neuropathic pain, and that this effect is mediated through the CB1 receptor.
Cannabis reduces opioid dose in the treatment of chronic non-cancer pain.
Occurrence and treatment of pain after brachial plexus injury.
TLDR
The occurrence of pain was investigated in 118 patients with posttraumatic brachial plexus injuries and the destruction of deafferented dorsal horns at the level of avulsion could produce pain relief when medical treatment failed.
Treatment of Refractory Pain after Brachial Plexus Avulsion with Dorsal Root Entry Zone Lesions
TLDR
Long-term follow-up monitoring of patients who underwent the dorsal root entry zone coagulation procedure in the cervical cord indicated that long-lasting satisfactory relief is possible for the majority of individuals, with acceptable morbidity rates.
...
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