Efficacy of troglitazone on body fat distribution in type 2 diabetes.

@article{Akazawa2000EfficacyOT,
  title={Efficacy of troglitazone on body fat distribution in type 2 diabetes.},
  author={Shiho Akazawa and Fei Sun and Michinori Ito and Eiji Kawasaki and Katsumi Eguchi},
  journal={Diabetes care},
  year={2000},
  volume={23 8},
  pages={1067-71}
}
OBJECTIVE The insulin-sensitizing action of troglitazone may be mediated through the activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and the promotion of preadipocyte differentiation in adipose tissue on which troglitazone has depot-specific effects. We investigated the relationship between efficacy of the drug and body fat distribution. Changes in body fat distribution were also investigated by long-term administration of the drug. RESEARCH DESIGN AND METHODS… CONTINUE READING