Efficacy of topical ivermectin and impact on quality of life in patients with papulopustular rosacea: A systematic review and meta‐analysis

  title={Efficacy of topical ivermectin and impact on quality of life in patients with papulopustular rosacea: A systematic review and meta‐analysis},
  author={Husein Husein-ElAhmed and Martin Steinhoff},
  journal={Dermatologic Therapy},
Rosacea is a chronic dermatosis which affects negatively patients' quality of life (QoL). There is shortage of high‐quality evidence comparing the efficacy of ivermectin cream (IVM) 1% with other available topical choices. Besides, the well‐documented impaired of self‐esteem and stigmatization of rosacea patients make essential to address which treatment provides the greatest psychological and social benefit. Our objective is to critically review and appraise the efficacy of IVM 1% in PPR and… Expand
7 Citations
Emerging topical drugs for the treatment of rosacea
The main unmet needs in the topical treatment of rosacea remain the management of vasomotor flushes and telangiectasias, as well as of troublesome symptoms such as burning and/or stinging. Expand
Evaluation of the efficacy of subantimicrobial dose doxycycline in rosacea: a systematic review of clinical trials and meta‐analysis
  • H. Husein-ElAhmed, M. Steinhoff
  • Medicine
  • Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2020
The efficacy of sub‐antimicrobial doses of SDD in papulopustular rosacea (PPR) is reviewed and the most suitable patients for this approach are determined. Expand
[Demodex and ocular surface disease].
Eyelid hygiene and oil-based ointments are the cornerstone of treatment, and new specific treatments based on tea tree oil, ivermectin, as well as pulsed light therapy and micro-exfoliation of the eyelid margin, can help to reduce the parasitic load and improve symptoms. Expand
Rosacea Treatment: Review and Update
The latest advances in rosacea treatment are summarized, including skin care and cosmetic treatments, topical therapies, oral therapies, laser- and light-based therapies, injection therapies, treatments for specific types of rosace, treatment for systemic comorbidities, and combination therapies. Expand
Ocular rosacea.
PURPOSE OF REVIEW To revisit ocular rosacea as an underappreciated condition which can cause permanent blindness if inadequately treated, and to review data supporting improved diagnostic andExpand
COVID‐19 related masks increase severity of both acne (maskne) and rosacea (mask rosacea): Multi‐center, real‐life, telemedical, and observational prospective study
Masks appear to trigger both acne and rosacea flares, and patients with acne displayed an increased Global Acne Grading Scale (GAGS) score in mask‐related areas and a statistically significant decrease in their quality of life. Expand
Bewertung der Wirksamkeit sub‐antimikrobieller Dosierungen von Doxycyclin bei Rosacea: Systematische Auswertung von klinischen Studien und Metaanalyse
Die Wirksamkeit sub‐antimikrobieller Dosen of Doxycyclin bei Rosacea papulopustulosa (RPP) untersucht, welche Patienten für diesen Behandlungsansatz am besten geeignet sind. Expand


Real‐life experience on effectiveness and tolerability of topical ivermectin in papulopustular rosacea and antiparasitic effect on Demodex mites
Ivermectin is an effective treatment not only in moderate to severe PPR but also in almost clear/mild rosacea and the antiparasitic effect on Demodex mites. Expand
Superior Efficacy with Ivermectin 1% Cream Compared to Metronidazole 0.75% Cream Contributes to a Better Quality of Life in Patients with Severe Papulopustular Rosacea: A Subanalysis of the Randomized, Investigator-Blinded ATTRACT Study
Better efficacy with IVM 1% cream (QD) compared to MTZ 0.75% twice daily (BID) contributes to an improved quality of life with significantly more patients achieving an MCID in DLQI score at week 16 and higher mean EQ-5D score. Expand
Ivermectin cream improves health‐related quality of life in patients with rosacea: data from a randomized trial
This analysis aims to compare the outcomes of treatments for rosacea by measuring the HRQoL using two patient-reported outcomes (PRO) instruments (DLQI, Dermatology Life Quality Index and EQ-5D) focusing on the long term, as results from the initial 16-week treatment for DLQI have been published elsewhere. Expand
Topical Ivermectin in the Treatment of Papulopustular Rosacea: A Systematic Review of Evidence and Clinical Guideline Recommendations
Topical ivermectin 1.0% cream is a new option having both anti-inflammatory and acaricidal activity against Demodex mites which might pave the way to a more etiologic approach in the treatment of papulopustular rosacea. Expand
The psychological impact of rosacea and the influence of current management options.
Patients with rosacea have higher incidences of embarrassment, social anxiety, depression, and decreased QoL compared with the rest of the population, and new options that target the facial erythema of roSacea may help mitigate the negative psychological impact. Expand
Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies.
Ivermectin 1% cream was effective and safe in treating inflammatory lesions of papulopustular rosacea and significantly more subjects receiving IVM 1% reported having an "excellent" or "good" improvement, along with an improved QoL. Expand
Ivermectin 1% (CD5024) for the treatment of rosacea
Though ivermectin 1% is a clinically efficacious medication, poor adherence continues to remain an issue due to topical application and the agent has the potential to be an effective drug when used as a single or combination agent. Expand
The efficacy, safety, and tolerability of ivermectin compared with current topical treatments for the inflammatory lesions of rosacea: a network meta-analysis
Ivermectin 1 % cream QD appears to be a more effective topical treatment than other current options for the inflammatory lesions of rosacea, with at least an equivalent safety and tolerability profile, and could provide physicians and dermatologists with an alternative first-line treatment option. Expand
Ivermectin: A Review in Rosacea
  • E. Deeks
  • Medicine
  • American Journal of Clinical Dermatology
  • 2015
Ivermectin 1 % cream is an effective and well tolerated option for the topical treatment of inflammatory lesions of rosacea, with the convenience of once-daily application. Expand
Health-related quality of life in patients with cutaneous rosacea: a systematic review.
It seems that rosacea has a small to moderate effect on HRQoL, which appeared to be associated with disease severity and age, and the association with sex and subtype was mixed. Expand