Efficacy of topical cyclosporine-loaded nanocapsules on keratoplasty rejection in the rat.

@article{Juberas1998EfficacyOT,
  title={Efficacy of topical cyclosporine-loaded nanocapsules on keratoplasty rejection in the rat.},
  author={Jos{\'e} Ram{\'o}n Juber{\'i}as and Margarita Calonge and Susana Gomez and Marcela I Lopez and Pilar Calvo and Jos{\'e} Mar{\'i}a Herreras and Maria Jose Castro Alonso},
  journal={Current eye research},
  year={1998},
  volume={17 1},
  pages={39-46}
}
PURPOSE To evaluate the efficacy of a topical formulation of nanocapsules loaded with 1% cyclosporine A (CsA), which has been previously demonstrated to enhance CsA corneal penetration, compared to 1% CsA in migliol oil on a penetrating keratoplasty rejection model in the rat. METHODS Lewis rats received orthotopic corneal allografts from inbred Fisher donors. Rats were treated with 10 microliters of the following topical solutions four times daily for 30 days, starting one day before surgery… CONTINUE READING

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