Efficacy of the combination of tobramycin and a macrolide in an in vitro Pseudomonas aeruginosa mature biofilm model.

@article{TrHardy2010EfficacyOT,
  title={Efficacy of the combination of tobramycin and a macrolide in an in vitro Pseudomonas aeruginosa mature biofilm model.},
  author={Marie Tr{\'e}-Hardy and Carole Nagant and Na{\"i}ma El Manssouri and Francis Vanderbist and Hamidou Traore and Mario Vaneechoutte and J. P. Dehaye},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 10},
  pages={
          4409-15
        }
}
Respiratory disease is the main cause of morbidity and mortality in patients with cystic fibrosis (CF). In particular, patients suffer from chronic infection due to biofilm formation by opportunistic Pseudomonas aeruginosa (32). Therefore, there is an urgent need to develop alternative ways to treat biofilm-associated clinical infections. The aim of this study was to compare the antimicrobial effects in vitro of the combinations tobramycin-clarithromycin and tobramycin-azithromycin against five… CONTINUE READING
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