Efficacy of the combination of N-acetylcysteine and desferrioxamine in the prevention and treatment of gentamicin-induced acute renal failure in male Wistar rats.

@article{Petronilho2009EfficacyOT,
  title={Efficacy of the combination of N-acetylcysteine and desferrioxamine in the prevention and treatment of gentamicin-induced acute renal failure in male Wistar rats.},
  author={Fabricia Petronilho and Larissa de Souza Constantino and Bruna de Souza and Adalisa Reinke and M{\'a}rcio Rodrigo Martins and Cassiana Mazon Fraga and Cristiane Ritter and Felipe Dal-Pizzol},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2009},
  volume={24 7},
  pages={
          2077-82
        }
}
BACKGROUND Oxidative stress and the formation of aminoglycoside-iron complexes through iron-dependent Fenton reaction have been proposed to be the major mechanisms in the development of GM-induced acute renal failure (ARF); however, the efficacy of the combination of N-acetylcysteine (NAC) and desferrioxamine (DFX) in the prevention and the treatment of GM-induced ARF has not previously been investigated. METHODS In the prevention protocol, adult male Wistar rats received gentamicin (GM) [70… CONTINUE READING

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