Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis.

@article{Spellberg2006EfficacyOT,
  title={Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis.},
  author={Brad J. Spellberg and Ashraf S Ibrahim and Valentina Avanesian and Yue Fu and Carter L Myers and Quynh Trang Phan and Scott G. Filler and Michael R Yeaman and John E. Edwards},
  journal={The Journal of infectious diseases},
  year={2006},
  volume={194 2},
  pages={256-60}
}
We have shown that vaccination with the recombinant N terminus of Als1p (rAls1p-N) protects mice against disseminated and oropharyngeal candidiasis. We now report that vaccination of mice with a related candidate, rAls3p-N, induces a broader antibody response than rAls1p-N and a similar cell-mediated immune response. The rAls3p-N vaccine was equally as effective as rAls1p-N against disseminated candidiasis but was more effective than rAls1p-N against oropharyngeal or vaginal candidiasis… CONTINUE READING
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