Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older.

@article{Cunningham2016EfficacyOT,
  title={Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older.},
  author={Amanda Leigh Cunningham and Himal Lal and Martina Kova{\vc} and Roman Chl{\'i}bek and S J Hwang and Javier D{\'i}ez-Domingo and Olivier Godeaux and Myron J. Levin and Janet E. Mcelhaney and Joan Puig-Barber{\`a} and Carline Vanden Abeele and Timo Vesikari and Daisuke Watanabe and Toufik Zahaf and Anitta Ahonen and Eugene Athan and Jos{\'e} Fernando do Barba-G{\'o}mez and Laura C{\'a}mpora and Ferdinandus J de Looze and Heather J. Downey and Wayne Ghesquiere and Iris Gorfinkel and Tiina Korhonen and Edward K. Leung and Shelly A McNeil and Lidia Oostvogels and Lars Rombo and Jan Smetana and Lily Weckx and Wilfred Winston Yeo and Thomas C. Heineman},
  journal={The New England journal of medicine},
  year={2016},
  volume={375 11},
  pages={
          1019-32
        }
}
BACKGROUND A trial involving adults 50 years of age or older (ZOE-50) showed that the herpes zoster subunit vaccine (HZ/su) containing recombinant varicella-zoster virus glycoprotein E and the AS01B adjuvant system was associated with a risk of herpes zoster that was 97.2% lower than that associated with placebo. A second trial was performed concurrently at the same sites and examined the safety and efficacy of HZ/su in adults 70 years of age or older (ZOE-70). METHODS This randomized… CONTINUE READING

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