Efficacy of slow infusion of diazoxide in the treatment of severe hypertension without organ hypoperfusion.

@article{Garrett1982EfficacyOS,
  title={Efficacy of slow infusion of diazoxide in the treatment of severe hypertension without organ hypoperfusion.},
  author={Ben Garrett and Norman M. Kaplan},
  journal={American heart journal},
  year={1982},
  volume={103 3},
  pages={390-4}
}
Diazoxide, as usually given in a single bolus, may cause precipitous falls in blood pressure (BP) with resultant tissue hypoperfusion. To examine the efficacy and safety of slow infusion, we treated 18 patients with mean initial BP of 220/143 mm Hg by two regimens: group A (nine patients) received 15 mg/minute; group B (nine patients) received 30 mg/minute. The goal of therapy, diastolic BP of 100 to 105 mm Hg, was reached in 16 of the 18 with no immediate drug-related side effects. Infusion… CONTINUE READING