Efficacy of single daily dosage of methimazole vs. propylthiouracil in the induction of euthyroidism

  title={Efficacy of single daily dosage of methimazole vs. propylthiouracil in the induction of euthyroidism},
  author={Mayuree Homsanit and Sutin Sriussadaporn and Sathit Vannasaeng and Thavatchai Peerapatdit and Wannee Nitiyanant and Apichati Vichayanrat},
  journal={Clinical Endocrinology},
Previous studies of the treatment of hyperthyroidism with a single daily dose of antithyroid drugs have demonstrated a favourable result with methimazole (MMI). However, the efficacy of a single daily dose of propylthiouracil (PTU) was inconsistent. The present prospective randomized study was conducted to compare the efficacy of a single daily dose of MMI and PTU in the induction of euthyroidism in patients with Graves' disease. 

Comparison of single daily dose of methimazole and propylthiouracil in the treatment of Graves’ hyperthyroidism

The efficacy of a single daily dose of methimazole (MMI) and propylthiouracil (PTU) in the treatment of Graves’ hyperthyroidism is compared.

Medical treatment of hyperthyroidism: state of the art.

Methimazole and propylthiouracil are the main antithyroid drugs used for hyperthyroidism and Rituximab, a monoclonal antibody directed against human CD20, was recently proposed as a biological therapy for cases of Graves' disease unresponsive to traditional drugs.

Antithyroid Drugs for the Treatment of Graves Disease A Randomized Clinical Trial

There were no significant differences between PTU and MMI groups in relation to remission rate, side effect profiles, and compliance rates, and individuals with higher baseline antibody titers presented a lower probability of long term remission of GD.

Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' disease.

MMI 15 mg/d is suitable for mild and moderate GD, whereas MMI 30 mg/D is advisable for severe cases, and PTU is not recommended for initial use.

The safety and efficacy of antithyroid drugs

  • F. Azizi
  • Medicine, Biology
    Expert opinion on drug safety
  • 2006
Investigations are needed to determine indications for such therapy in children, adolescents and adults with diffuse toxic goiter, in particular, in those who have had recurrence of hyperthyroidism after discontinuation of one complete course of treatment.

Hyperthyroidism: advantages and disadvantages of medical therapy.

Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mg/Day) of Methimazole in the Induction of Euthyroidism in Graves' Hyperthyroidism: A Randomized Controlled Study

Treatment with MMI at a low daily dosage of 15 mg/day OD-MMI is as effective as DD-M MI in the reduction of serum thyroid hormone levels and induction of euthyroidism and the OD- MMI regimen is preferable in the treatment of clinically nonsevere Graves' hyperthyroidism.

A Study of Carbimazole Treatment in Hyperthyroidism Comparsion with Radioiodine

Radioiodine is the most effective treatment for controlling the hyperthyroidism but hypothyroidism is a common complication.

Change in the intrathyroidal kinetics of radioiodine under continued and discontinued antithyroid medication in Graves’ disease

Efficacy of radioiodine therapy under continued thiamazole medication is reduced not only by a lower uptake and shorter half-life ofRadioiodine, but also by a heterogeneous energy dose distribution in the thyroid.

Short-term effects of combined treatment with potassium bromide and methimazole in patients with Graves’ disease

Treatment of patients with Graves’ disease with a novel combination therapy consisting of potassium bromide and methimazole resulted in a rapid improvement in clinical symptoms and decreased blood thyroid hormone levels to homeostatic levels faster than methIMazole treatment alone.



Single Daily Dose of Methimazole Compared to Every 8 Hours Propylthiouracil in the Treatment of Hyperthyroidism

ABSTRACT:This study to compare single-dose and multiple-dose antithyroid therapy was prompted by a perceived lack of compliance in our University Medical Clinics by those patients using multidose


Therapy is generally limited to one of two thionamide derivatives, propylthiouracil and methimazole, which are relatively nontoxic and are used as a definitive form of medical management, in the preparation of thyrotoxic patients for thyroidectomy or, occasionally, to ensure some control of the disease in the period after therapy with radioactive iodine while one is waiting for the radiation effect to become manifest.

A comparison of 20 or 40 mg per day of carbimazole in the initial treatment of hyperthyroidism

OBJECTIVE The optimal dosage regimen for carbimazole (CBZ) in the treatment of hyperthyroidism remains uncertain, despite clinical use of the drug for approximately fifty years. We have compared the

Single-dose, “Block-Replace” Drug Therapy in Hyperthyroidism

In 30 consecutive hyperthyroid patients with diffuse goitre divided dose therapy with carbimazole 40 mg and triiodothyronine 80 μg daily was shown to produce total or subtotal block in thyroid

The use of antithyroid drugs in a single daily dose. Treatment of diffuse toxic goiter.

Of 41 patients in whom a euthyroid state was induced with the usual multiple daily dose plan, 28 continued in remission for the remainder of their treatment when given the same amount of medication as a single dose before breakfast, and 11 patients whose remission could not be maintained with the single daily dose.

Treatment of hyperthyroidism with a small single daily dose of methimazole.

It is concluded that the single daily dose regimen of 15 mg of methimazole will control Graves' hyperthyroidism in most patients, and TSH binding inhibitor immunoglobulin levels decrease in this regimen in the same way as with the conventional divided dose regimen.

Treatment of hyperthyroidism with a small single daily dose of methimazole: a prospective long-term follow-up study.

There is no difference in the clinical and immunological course or in the long-term remission rate of Graves' hyperthyroidism when the treatment is initiated with either a small single daily dose (15 mg) or the conventional regimen (10 mg 3 times daily).

Single daily dose of methimazole compared to every 8 hours propylthiouracil in the treatment of hyperthyroidism.

Once-a-day methimazole therapy was just as effective as propylthiouracil every 8 hours in improving thyroid indices and clinical markers in this population of hyperthyroid patients and Compliance was also improved with the once- a-day therapy.

Single daily dose of carbimazole in the treatment of hyperthyroidism.

It is concluded that carbimazole in a single daily dose is an effective method for treating hyperthyroidism in an area of mild iodine deficiency and its efficacy is comparable to divided dose therapy.


Twenty‐one patients with hyperthyroid Graves’disease were treated with carbimazole 30 mg daily, given as a single dose and seven have remained in remission fromhyperthyroidism for more than one year.