Efficacy of single daily dosage of methimazole vs. propylthiouracil in the induction of euthyroidism

@article{Homsanit2001EfficacyOS,
  title={Efficacy of single daily dosage of methimazole vs. propylthiouracil in the induction of euthyroidism},
  author={Mayuree Homsanit and Sutin Sriussadaporn and Sathit Vannasaeng and Thavatchai Peerapatdit and Wannee Nitiyanant and Apichati Vichayanrat},
  journal={Clinical Endocrinology},
  year={2001},
  volume={54}
}
Previous studies of the treatment of hyperthyroidism with a single daily dose of antithyroid drugs have demonstrated a favourable result with methimazole (MMI). However, the efficacy of a single daily dose of propylthiouracil (PTU) was inconsistent. The present prospective randomized study was conducted to compare the efficacy of a single daily dose of MMI and PTU in the induction of euthyroidism in patients with Graves' disease. 
Comparison of single daily dose of methimazole and propylthiouracil in the treatment of Graves’ hyperthyroidism
TLDR
The efficacy of a single daily dose of methimazole (MMI) and propylthiouracil (PTU) in the treatment of Graves’ hyperthyroidism is compared.
Medical treatment of hyperthyroidism: state of the art.
TLDR
Methimazole and propylthiouracil are the main antithyroid drugs used for hyperthyroidism and Rituximab, a monoclonal antibody directed against human CD20, was recently proposed as a biological therapy for cases of Graves' disease unresponsive to traditional drugs.
Antithyroid Drugs for the Treatment of Graves Disease A Randomized Clinical Trial
TLDR
There were no significant differences between PTU and MMI groups in relation to remission rate, side effect profiles, and compliance rates, and individuals with higher baseline antibody titers presented a lower probability of long term remission of GD.
Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' disease.
TLDR
MMI 15 mg/d is suitable for mild and moderate GD, whereas MMI 30 mg/D is advisable for severe cases, and PTU is not recommended for initial use.
The safety and efficacy of antithyroid drugs
  • F. Azizi
  • Medicine
    Expert opinion on drug safety
  • 2006
TLDR
Investigations are needed to determine indications for such therapy in children, adolescents and adults with diffuse toxic goiter, in particular, in those who have had recurrence of hyperthyroidism after discontinuation of one complete course of treatment.
Hyperthyroidism: advantages and disadvantages of medical therapy.
TLDR
Hyperthyroidism can be treated medically with antithyroid drugs or radioactive iodine, or surgically, or with other forms of therapy.
Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mg/Day) of Methimazole in the Induction of Euthyroidism in Graves' Hyperthyroidism: A Randomized Controlled Study
TLDR
Treatment with MMI at a low daily dosage of 15 mg/day OD-MMI is as effective as DD-M MI in the reduction of serum thyroid hormone levels and induction of euthyroidism and the OD- MMI regimen is preferable in the treatment of clinically nonsevere Graves' hyperthyroidism.
Antithyroid drugs in the management of patients with Graves' disease: an evidence-based approach to therapeutic controversies.
  • D. Cooper
  • Medicine
    The Journal of clinical endocrinology and metabolism
  • 2003
TLDR
The cases of two prototypical patients that are likely to be seen frequently in any busy clinical endocrinologist’s office will be presented and a series of questions about each case will be raised and then answered using level A evidence, wherever possible.
A Study of Carbimazole Treatment in Hyperthyroidism Comparsion with Radioiodine
Background and Objective: Hyperthyroidism is a common clinical disorder all over world. Even though diagnosis in hyperthyroidism is generally straight forward, its prevalence varies among population.
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ABSTRACT:This study to compare single-dose and multiple-dose antithyroid therapy was prompted by a perceived lack of compliance in our University Medical Clinics by those patients using multidose
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TLDR
Therapy is generally limited to one of two thionamide derivatives, propylthiouracil and methimazole, which are relatively nontoxic and are used as a definitive form of medical management, in the preparation of thyrotoxic patients for thyroidectomy or, occasionally, to ensure some control of the disease in the period after therapy with radioactive iodine while one is waiting for the radiation effect to become manifest.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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