Efficacy of scorpion antivenom plus prazosin versus prazosin alone for Mesobuthus tamulus scorpion sting envenomation in children: a randomised controlled trial

  title={Efficacy of scorpion antivenom plus prazosin versus prazosin alone for Mesobuthus tamulus scorpion sting envenomation in children: a randomised controlled trial},
  author={Karuppiah Pandi and Sriram Krishnamurthy and Rangan Srinivasaraghavan and Subramanian Mahadevan},
  journal={Archives of Disease in Childhood},
  pages={575 - 580}
Objective To assess the efficacy of combined use of scorpion antivenom (SAV) with prazosin, compared with prazosin alone in children with Mesobuthus tamulus scorpion envenomation. Study design Randomised controlled trial. Setting A tertiary care hospital in south India. Patients 50 children with definite history and/or systemic manifestations of scorpion envenomation were recruited from the paediatric emergency or outpatient department from February 2012 to July 2013. Interventions The children… 

Second Dose of Scorpion Antivenom in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation

Children with severe scorpion sting envenomation with abnormal echocardiography may require a higher dose of scorpion antivenom.

Efficacy of Scorpion Antivenom in Grade III and IV Scorpion Envenomation

Prazosin and supportive treatment has improved the outcome in pediatric age group and points towards the beneficial role of antivenom in the Pediatrics age group.

Management of scorpion envenoming: a systematic review and meta-analysis of controlled clinical trials

BackgroundScorpion stings cause an estimated 3000 deaths per annum worldwide. We conducted a systematic review of all controlled clinical trials related to scorpion sting management.MethodsWe

Comparing clinical outcomes between two scorpion antivenom dosing strategies in children

A retrospective analysis of medical records of pediatric patients treated in the pediatric emergency department with grade 3 or 4 envenomation requiring antivenom found no statistically significant differences between the two groups regarding clinical outcomes including PED discharge, intubation, hospitalization, or death.

Comparison of antivenom effects between pediatric and adult patients presented to emergency department with scorpion stings

This study included 99 patients who were admitted to the emergency department with scorpion sting within 1 year and the mean age of patients who received antivenom was statistically significantly lower than the patients who did not receive antivenoms.

Predictors of myocardial dysfunction in children with indian red scorpion (Mesobuthus tamulus) sting envenomation

Early (<4 hours) administration of Scorpion antivenom along with prazosin increases the cumulative percentage of children not developing myocardial dysfunction.

Clinical update on scorpion envenoming.

  • P. Cupo
  • Medicine, Biology
    Revista da Sociedade Brasileira de Medicina Tropical
  • 2015
Clinical data point to catecholamine excess as the cause for reversible scorpion cardiomyopathy, and the efficiency of antivenom serum treatment is controversial in the literature.

Scorpion Envenomation in Pregnancy

After thorough review of the treatment modalities that are used to treat scorpion envenomation, a treatment algorithm is developed that may help guide the management of pregnant women who present with scorpions.

Neurological and Systemic Manifestations of Severe Scorpion Envenomation

The aim of this review is to clarify the epidemiologic characteristics and clinical manifestations as well as diagnosis and management of neurologic complications following scorpion envenomation.



Utility of scorpion antivenin vs prazosin in the management of severe Mesobuthus tamulus (Indian red scorpion) envenoming at rural setting.

It is found that SAV is no more effective to alleviate or reverse the cardiovascular effects of scorpion venom actions in severe case as against prazosin prevents and cures the cardiovascular manifestations in a severe scorpion envenomation.

Antivenom for critically ill children with neurotoxicity from scorpion stings.

intravenous administration of scorpion-specific F(ab')(2) antivenom resolved the clinical syndrome within 4 hours, reduced the need for concomitant sedation with midazolam, and reduced the levels of circulating unbound venom.

Efficacy of anti-scorpion venom serum over prazosin in the management of severe scorpion envenomation.

Intravenous slow bolus of AScVS given based on the clinical severity of envenomation leads to early recovery than prazosin alone and is well tolerated.

The treatment of the scorpion envenoming syndrome: the Saudi experience with serotherapy.

  • M. Ismail
  • Medicine
    Toxicon : official journal of the International Society on Toxinology
  • 1994

Meta-analysis of controlled studies on immunotherapy in severe scorpion envenomation

SAV should not be administered in Old World scorpion envenomation until its efficacy is established by an appropriately designed RCT, and in the Arizona scorpion sting, SAV hastens the recovery process.

Scorpion envenomation and serotherapy in Morocco.

It is demonstrated that antivenom is effective in decreasing circulating venom and morbidity and Serotherapy is more efficient when given as soon as possible after envenomation and with adequate quantities of antivenOM.

Efficacy of species specific anti-scorpion venom serum (AScVS) against severe, serious scorpion stings (Mesobuthus tamulus concanesis Pocock)--an experience from rural hospital in western Maharashtra.

AScVS is effective and safe method of therapy in severe scorpion envenoming syndrome and was faster than those who received alpha blockers and no anaphylactic reaction with AScVS was observed.

A retrospective analysis of a rural set up experience with special reference to dobutamine in prazosin-resistant scorpion sting cases.

  • Suvarna N. Patil
  • Medicine
    The Journal of the Association of Physicians of India
  • 2009
In initial phases of autonomic storm i.e. accelerated hypertension one can use prazosin but monitor the patient for left ventricular failure and clinically if patient develops LVF add dobutamine to prevent death.

Scorpion sting: update.

Since the advent of scorpion Antivenom, vasodilators, dobutamine and intensive care facilities, the fatality due to severe scorpion sting has been significantly reduced in areas where these treatment modalities are used.