Efficacy of rituximab treatment for thyroid-associated ophthalmopathy as a result of intraorbital B-cell depletion in one patient unresponsive to steroid immunosuppression.

@article{Salvi2006EfficacyOR,
  title={Efficacy of rituximab treatment for thyroid-associated ophthalmopathy as a result of intraorbital B-cell depletion in one patient unresponsive to steroid immunosuppression.},
  author={Mario Salvi and Guia M Vannucchi and Irene Campi and Stefania Rossi and Paola Bonara and Francesco Sbrozzi and C. Guastella and Sabrina Avignone and Giacinta Pirola and Roberto Ratiglia and Paolo Beck-Peccoz},
  journal={European journal of endocrinology},
  year={2006},
  volume={154 4},
  pages={
          511-7
        }
}
One patient with Graves' hyperthyroidism and ophthalmopathy in its active phase and unresponsive to steroid, was treated with the anti-CD20 monoclonal antibody, rituximab (RTX), as part of an open study. The effect of RTX in the thyroid and the orbital tissues was studied. The ophthalmopathy responded to RTX therapy by ameliorating the eye signs with a decrease in the clinical activity score from 5 to 2 in 3 months, while the patient had peripheral B-cell depletion. Hyperthyroidism did not… CONTINUE READING
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