Efficacy of quadrivalent HPV vaccine against HPV Infection and disease in males.

  title={Efficacy of quadrivalent HPV vaccine against HPV Infection and disease in males.},
  author={Anna Regina Giuliano and Joel M Palefsky and Stephen Goldstone and Edson Duarte Moreira and Mary Edith Penny and Carlos Aranda and Eftyhia Vardas and Harald Moi and Heiko K. Jessen and Richard John Hillman and Y Chang and Daron G. Ferris and Danielle Rouleau and Janine Bryan and J Brooke Marshall and Scott C Vuocolo and Eliav Barr and David Radley and Richard M. Haupt and Dalya Guris},
  journal={The New England journal of medicine},
  volume={364 5},
BACKGROUND Infection with human papillomavirus (HPV) and diseases caused by HPV are common in boys and men. We report on the safety of a quadrivalent vaccine (active against HPV types 6, 11, 16, and 18) and on its efficacy in preventing the development of external genital lesions and anogenital HPV infection in boys and men. METHODS We enrolled 4065 healthy boys and men 16 to 26 years of age, from 18 countries in a randomized, placebo-controlled, double-blind trial. The primary efficacy… CONTINUE READING
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