Efficacy of providing nicotine in a liquid diet to rats.

@article{Halladay1999EfficacyOP,
  title={Efficacy of providing nicotine in a liquid diet to rats.},
  author={Alycia K. Halladay and Martin Schwartz and George W. Wagner and Michael M. Iba and Andrzej Sekowski and Hans Fisher},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1999},
  volume={221 3},
  pages={215-23}
}
To determine if rats would consume nicotine at psychoactive levels, a nutritionally balanced diet with 0, 20, 60, or 200 mg of nicotine tartrate per kg of diet was provided. Diet consumption and body weight differences were recorded for 14 days after which, following 16 hr of withdrawal, animals were given access to a two-bottle choice of the previously presented diet and a nicotine-free diet. Spontaneous horizontal motor activity was recorded 8, 16, and 24 hr after withdrawal. By Day 14, all… CONTINUE READING