Efficacy of progesterone on threatened miscarriage: an updated meta-analysis of randomized trials

  title={Efficacy of progesterone on threatened miscarriage: an updated meta-analysis of randomized trials},
  author={Yuying Yan and Zeping Chen and Ying Yang and Xinkuo Zheng and Meijuan Zou and Gang Cheng and Zhenting Yuan},
  journal={Archives of Gynecology and Obstetrics},
Purpose The efficacy of progesterone supplementation in the treatment of threatened miscarriage is controversial. This meta-analysis was to evaluate the correlation between progesterone and improving pregnancy outcomes in women with threatened miscarriage. Methods We searched PubMed, EMBASE, and the Cochrane Library for relevant randomized controlled trials (RCTs) to demonstrate the efficacy of progesterone on the threatened miscarriage pregnancy. The outcomes were miscarriage, preterm birth… 
2 Citations
Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine
The aim of this work is to show the mechanisms of action of progesterone and its metabolites, the physiological and pharmacological actions of prog estrogen and its synthetic analogues in human medicine, as well as the impacts of its production and use on the environment.
Real‐world pharmacological treatment patterns of patients with threatened miscarriage in China from 2014 to 2020: A cross‐sectional analysis
The goal was to investigate the real‐world pharmacological treatment patterns of patients with threatened miscarriage in China, with a focus on the trend and rationality of progestogen use over the last 7 years.


The Influence of Oral Dydrogesterone and Vaginal Progesterone on Threatened Abortion: A Systematic Review and Meta-Analysis
Progesterone therapy, especially oral dydrogestersterone, can effectively prevent miscarriage in pregnant women experiencing threatened abortion.
Micronized vaginal progesterone to prevent miscarriage: a critical evaluation of randomized evidence
Women with a history of miscarriage who present with bleeding in early pregnancy may benefit from the use of vaginal micronized progesterone 400 mg twice daily, and women and their care providers should use the findings for shared decision-making.
Progestogen for treating threatened miscarriage.
The data suggest that the use of progestogens is effective in the treatment of threatened miscarriage with no evidence of increased rates of pregnancy-induced hypertension or antepartum haemorrhage as harmful effects to the mother, nor increased occurrence of congenital abnormalities on the newborn.
The Effect of Progesterone Suppositories on Threatened Abortion: A Randomized Clinical Trial
The study demonstrated that the rate of abortion was reduced in women treated with progesterone suppository, however, the difference was not statistically significant.
Dydrogesterone in threatened abortion: Pregnancy outcome
Progesterone and threatened abortion: a randomized clinical trial on endocervical cytokine concentrations.
A Randomized Trial of Progesterone in Women with Bleeding in Early Pregnancy
Progesterone therapy administered during the first trimester did not result in a significantly higher incidence of live births than placebo and the incidence of adverse events did not differ significantly between the groups.
Effects of Vaginal Progesterone on Pain and Uterine Contractility in Patients with Threatened Abortion before Twelve Weeks of Pregnancy
The use of vaginal progesterone improved the outcome of pregnancies complicated by threatened abortion and previous diagnosis of inadequate luteal phase, and was effective both on pain relief and on the frequency of the UCs that decreased after 5 days of vaginal PROGesterone administration.