Efficacy of phloroglucinol for treatment of abdominal pain: a systematic review of literature and meta-analysis of randomised controlled trials versus placebo

@article{Blanchard2018EfficacyOP,
  title={Efficacy of phloroglucinol for treatment of abdominal pain: a systematic review of literature and meta-analysis of randomised controlled trials versus placebo},
  author={Clara Blanchard and Denis Pouchain and Paul Vanderkam and Marie-Christine P{\'e}rault-Pochat and R{\'e}my Boussageon and H{\'e}l{\`e}ne Vaillant-Roussel},
  journal={European Journal of Clinical Pharmacology},
  year={2018},
  volume={74},
  pages={541-548}
}
AimPhloroglucinol is a musculotropic anti-spasmodic drug. [] Key MethodResultsThree RCT were included and then analysed for risk of bias and meta-analysed. Only one RCT found that phloroglucinol was superior to placebo, although with a high risk of bias. The meta-analysis found a risk ratio of 1.10 (95% CI 0.95, 1.27) with no statistical significance.DiscussionThere is insufficient data to justify the wide-spread prescription of phloroglucinol for alleviating abdominal pain.

Efficacy of phloroglucinol for the treatment of pain of gynaecologic or obstetrical origin: a systematic review of literature of randomised controlled trials

The results found are insufficient to promote the use of this drug in these indications, whether for labour pains, abortion pains or benign gynaecologic pains.

Efficacy of phloroglucinol for the treatment of pain of gynaecologic or obstetrical origin: a systematic review of literature of randomised controlled trials

The results found are insufficient to promote the use of this drug in these indications and a quantitative synthesis (meta-analysis) was planned if the included trials were sufficiently homogenous.

Effectiveness of oral phloroglucinol as a premedication for unsedated esophagogastroduodenoscopy: A prospective, double-blinded, placebo-controlled, randomized trial

Oral phloroglucinol significantly suppressed gastrointestinal peristalsis during unsedated EGD compared with placebo, and patients in both groups had comparable adverse events and showed willingness to take the premedication at their next examination.

Effect of Intravenous Phloroglucinol Injections upon duration of Active First Stage of Labor

PHL is a useful drug serving the purpose of a spasmolytic, analgesic and labor augmentation at the same time, and efficiently reduced the duration of active first stage of labor in randomly selected nulliparous and multiparous women.

Finally an evidence-based indication for injectable phloroglucinol!

Intestinal, urinary and uterine antispasmodic effects of isoespintanol, metabolite from Oxandra xylopioides leaves.

Phloroglucinol inhibits oxytocin-induced contraction in rat gastric circular muscle and uterine smooth muscle.

  • Wen-Jia YangHua Guo Nan Sun
  • Biology, Medicine
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • 2022
Phloroglucinol could attenuate PD and inhibit the contraction of rat gastric circular muscle and uterine smooth muscle induced by OT, and provides novel ideas for the role of phloroglucainol in PD development.

Risk factors of uterine contraction after ureteroscopy in pregnant women with renal colic

No history of childbirth, shorter operation time, application of phloroglucinol, pain relief after surgery are protective factors, and SIRS occurred after surgery is a risk factor for uterine contraction.

Anticancer Properties and Mechanism of Action of Oblongifolin C, Guttiferone K and Related Polyprenylated Acylphloroglucinols

The origin, method of extraction and biological properties of oblongifolin C and guttiferone K, isolated from Garcinia species, and a focus on the targets and pathways implicated in their anticancer activities are presented.

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