Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis

@article{Luthra2019EfficacyOP,
  title={Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis},
  author={Pavit Luthra and N. Burr and D. Brenner and A. Ford},
  journal={Gut},
  year={2019},
  volume={68},
  pages={434 - 444}
}
Objective Opioids are increasingly prescribed in the West and have deleterious GI consequences. Pharmacological therapies to treat opioid-induced constipation (OIC) are available, but their relative efficacy is unclear. We performed a systematic review and network meta-analysis to address this deficit in current knowledge. Design We searched MEDLINE, EMBASE, EMBASE Classic and the Cochrane central register of controlled trials through to December 2017 to identify randomised controlled trials… Expand
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