Efficacy of pergolide in treatment of restless legs syndrome: the PEARLS Study.

@article{Trenkwalder2004EfficacyOP,
  title={Efficacy of pergolide in treatment of restless legs syndrome: the PEARLS Study.},
  author={Claudia Trenkwalder and H-P Hundemer and Alberto Garc{\'i}a Lled{\'o} and John Swieca and Olli Polo and Thomas C. Wetter and Luigi Ferini-Strambi and H de Groen and Deborah C Quail and U. Brandenburg},
  journal={Neurology},
  year={2004},
  volume={62 8},
  pages={1391-7}
}
OBJECTIVE To evaluate the short- and long-term safety and efficacy of pergolide therapy for restless legs syndrome (RLS) in a double-blind, placebo-controlled, randomized trial (Pergolide European Australian RLS [PEARLS] study). METHODS We randomized 100 patients with idiopathic RLS were randomized to pergolide, 0.25 to 0.75 mg, in the evening or placebo for 6 weeks (phase 1); thereafter, patients with response on the Patient Global Impression (PGI) scale continued on double-blind pergolide… CONTINUE READING
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