Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial.

@article{Keller2001EfficacyOP,
  title={Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial.},
  author={Martin Keller and Neal D. Ryan and Michael Strober and Rachel Gittelman Klein and Stan Kutcher and Boris Birmaher and O. R. Hagino and Harold S. Koplewicz and Gabrielle A. Carlson and Gregory Clarke and Graham J. Emslie and D Feinberg and Barbara Geller and Vivek Kusumakar and George Makrydimas Stefania Papatheodorou and William H. Sack and Melissa Sweeney and Karen Dineen Wagner and Elizabeth B. Weller and Nancy C. Winters and Rosemary Oakes and James P. Mccafferty},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  year={2001},
  volume={40 7},
  pages={
          762-72
        }
}
  • M. Keller, N. Ryan, J. Mccafferty
  • Published 1 July 2001
  • Psychology, Medicine
  • Journal of the American Academy of Child and Adolescent Psychiatry
OBJECTIVE To compare paroxetine with placebo and imipramine with placebo for the treatment of adolescent depression. METHOD After a 7- to 14-day screening period, 275 adolescents with major depression began 8 weeks of double-blind paroxetine (20-40 mg), imipramine (gradual upward titration to 200-300 mg), or placebo. The two primary outcome measures were endpoint response (Hamilton Rating Scale for Depression [HAM-D] score < or = 8 or > or = 50% reduction in baseline HAM-D) and change from… 
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