Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial.

@article{Keller2001EfficacyOP,
  title={Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial.},
  author={M. Keller and N. Ryan and M. Strober and R. Klein and S. Kutcher and B. Birmaher and O. Hagino and H. Koplewicz and G. Carlson and G. Clarke and G. Emslie and D. Feinberg and B. Geller and V. Kusumakar and G. Papatheodorou and W. Sack and M. Sweeney and K. Wagner and E. Weller and Nancy C. Winters and Rosemary Oakes and J. McCafferty},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  year={2001},
  volume={40 7},
  pages={
          762-72
        }
}
  • M. Keller, N. Ryan, +19 authors J. McCafferty
  • Published 2001
  • Psychology, Medicine
  • Journal of the American Academy of Child and Adolescent Psychiatry
  • OBJECTIVE To compare paroxetine with placebo and imipramine with placebo for the treatment of adolescent depression. METHOD After a 7- to 14-day screening period, 275 adolescents with major depression began 8 weeks of double-blind paroxetine (20-40 mg), imipramine (gradual upward titration to 200-300 mg), or placebo. The two primary outcome measures were endpoint response (Hamilton Rating Scale for Depression [HAM-D] score < or = 8 or > or = 50% reduction in baseline HAM-D) and change from… CONTINUE READING
    575 Citations
    Paroxetine treatment in children and adolescents with major depressive disorder: a randomized, multicenter, double-blind, placebo-controlled trial.
    • 112
    Paroxetine in the treatment of adolescent major depression.
    • 3
    • PDF
    An international, multicenter, placebo-controlled trial of paroxetine in adolescents with major depressive disorder.
    • 80
    • PDF
    Fluoxetine for acute treatment of depression in children and adolescents: a placebo-controlled, randomized clinical trial.
    • 505
    • PDF
    Paroxetine versus clomipramine in adolescents with severe major depression: a double-blind, randomized, multicenter trial.
    • 68
    Remission and residual symptoms after short-term treatment in the Treatment of Adolescents with Depression Study (TADS).
    • B. Kennard, S. Silva, +12 authors J. March
    • Psychology, Medicine
    • Journal of the American Academy of Child and Adolescent Psychiatry
    • 2006
    • 211
    A double-blind, randomized, placebo-controlled trial of escitalopram in the treatment of pediatric depression.
    • 178

    References

    SHOWING 1-10 OF 80 REFERENCES
    Response to desipramine treatment in adolescent depression: a fixed-dose, placebo-controlled trial.
    • 116
    A randomized, controlled trial of amitriptyline in the acute treatment of adolescent major depression.
    • 87
    A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression.
    • 908
    Adolescent depression: Controlled desipramine treatment and atypical features
    • 44
    Multicenter open-label sertraline study in adolescent outpatients with major depression.
    • 84
    Paroxetine in depressed adolescents with intellectual disability: an open label study.
    • 28
    • Highly Influential
    An open study of the effects of sertraline on adolescent major depression.
    • 48
    • Highly Influential
    The pharmacotherapy of depressive illness in adolescents: an open-label comparison of fluoxetine with imipramine-treated historical controls.
    • 23
    Randomized, controlled trial of amitriptyline versus placebo for adolescents with "treatment-resistant" major depression.
    • 119