Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial.

@article{Keller2001EfficacyOP,
  title={Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial.},
  author={M. Keller and N. Ryan and M. Strober and R. Klein and S. Kutcher and B. Birmaher and O. Hagino and H. Koplewicz and G. Carlson and G. Clarke and G. Emslie and D. Feinberg and B. Geller and V. Kusumakar and G. Papatheodorou and W. Sack and M. Sweeney and K. Wagner and E. Weller and Nancy C. Winters and Rosemary Oakes and J. McCafferty},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  year={2001},
  volume={40 7},
  pages={
          762-72
        }
}
  • M. Keller, N. Ryan, +19 authors J. McCafferty
  • Published 2001
  • Psychology, Medicine
  • Journal of the American Academy of Child and Adolescent Psychiatry
    • OBJECTIVE To compare paroxetine with placebo and imipramine with placebo for the treatment of adolescent depression. METHOD After a 7- to 14-day screening period, 275 adolescents with major depression began 8 weeks of double-blind paroxetine (20-40 mg), imipramine (gradual upward titration to 200-300 mg), or placebo. The two primary outcome measures were endpoint response (Hamilton Rating Scale for Depression [HAM-D] score < or = 8 or > or = 50% reduction in baseline HAM-D) and change from… CONTINUE READING
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