Efficacy of oral cobalamin (vitamin B12) therapy

@article{Andrs2010EfficacyOO,
  title={Efficacy of oral cobalamin (vitamin B12) therapy},
  author={Emmanuel Andr{\`e}s and Helen Fothergill and Mustapha Mecili},
  journal={Expert Opinion on Pharmacotherapy},
  year={2010},
  volume={11},
  pages={249 - 256}
}
Importance of the field: Cobalamin (vitamin B12) deficiency is particularly common in the elderly (> 15%). Management of cobalamin deficiency with cobalamin injections is well codified at present, but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption. Areas covered in this review: The objective of this review is to evaluate the efficacy of oral cobalamin treatment in elderly patients. To reach this… 
State of Art of Oral Vitamin B12 (Cobalamin) in Biermer’s Disease (Pernicious Anemia)
Management of cobalamin deficiency with vitamin B12 injections is currently well codified, but new routes of vitamin B12 administration (oral and nasal) are being studied. In the setting of Biermer’s
State of art of oral vitamin B12 (cobalamin) treatment in Biermer's disease (pernicious anemia)
TLDR
Evidence that oral vitamin B12 treatment may adequately treat cobalamin deficiency and Biermer’s disease is found and the efficacy was documented with a marked improvement in serum vitamin B 12 levels or normalization of this latter.
Review of oral vitamin B12 (cobalamin) therapy
TLDR
Evidence that oral vitamin B12 treatment may adequately treat cobalamin deficiency is provided and the efficacy was particularly highlighted when looking at the marked improvement in serum vitamin B 12 levels and hematological parameters.
Oral vitamin B12 for patients suspected of subtle cobalamin deficiency: a multicentre pragmatic randomised controlled trial
TLDR
Oral vitamin B12 treatment normalised the metabolic markers of vitamin B 12 deficiency, however, a one-month daily treatment was not sufficient to normalise the deficiency markers for four months, and treatment had no effect on haematological signs of B12 deficiency.
[Oral vitamin B12: Efficacy and safety data in 31 patients with pernicious anemia and food-cobalamin malabsorption].
TLDR
This study confirms the efficacy and safety of oral cobalamin therapy in food-cobalamin malabsorption and also in case of pernicious anemia.
Oral vitamin B 12 for patients suspected of subtle cobalamin deficiency : a multicentre pragmatic randomised controlled trial
Background: Evidence regarding the effectiveness of oral vitamin B12 in patients with serum vitamin B12 levels between 125-200 pM/l is lacking. We compared the effectiveness of one-month oral vitamin
Efficacité et tolérance de la vitamine B12 par voie orale chez 31 patients avec une maladie de Biermer ou une maldigestion des cobalamines alimentaires
TLDR
This study confirms the efficacy and safety of oral cobalamin therapy in food-cobalamin malabsorption and also in case of pernicious anemia.
Oral cobalamin therapy: it may be perhaps time to propose international recommendations?
TLDR
Oral cobalamin therapy with daily high-dose (pharmacological dose, of at least 1000 mg per day) oral vitamin B12 can cure cobalam deficiency and may also induce and maintain remission in patients with megaloblastic anemia.
Vitamin B12 deficiency in patients undergoing bariatric surgery: preventive strategies and key recommendations.
TLDR
Patients undergoing bariatric surgery must be continuously educated on proper nutrition, the risk of developing significant vitamin B12 deficiency, and the role of supplements in avoiding catastrophic consequences.
Systematic Review and Pragmatic Clinical Approach to Oral and Nasal Vitamin B12 (Cobalamin) Treatment in Patients with Vitamin B12 Deficiency Related to Gastrointestinal Disorders
TLDR
It is concluded that oral vitamin B 12 is an effective alternative to intramuscular vitamin B12 (except in patients presenting with severe neurological manifestations), and thus, with safety profile, and Oral vitamin B11 treatment avoids the discomfort, contraindication, and cost of monthly injections.
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TLDR
This present review confirms the previously reported efficacy of oral cobalamin treatment in adult and elderly patients and confirms that at least 1000 μg/day of oral cyanocobalmin are needed for pernicious anemia and a mean daily dose of 250’μg for food‐cobalamin malabsorption.
Treatment of Vitamin B12–Deficiency Anemia: Oral versus Parenteral Therapy
TLDR
There are inadequate data at the present time to support the use of oral cyanocobalamin replacement in patients with severe neurologic involvement, and several studies provide evidence that daily oral cyanOCobalamin as opposed to monthly parenteral formulations may adequately treat both types of cobalamin-deficient anemias.
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TLDR
The findings suggest that moderate doses of crystalline cyanocobalamin given orally may be an effective treatment for food-cobalamin malabsorption.
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TLDR
Crystalline cyanocobalamin, 250-1000 microg/day, given orally for 1 month, may be an effective treatment for cobalamin deficiencies not related to pernicious anemia.
Hematological response to short-term oral cyanocobalamin therapy for the treatment of cobalamin deficiencies in elderly patients.
TLDR
The view that one month of oral crystalline cyanocobalamin is effective to correct serum vitamin B12 levels and to obtain hematological responses in elderly patients with cobalamin deficiency related to food-cobalamin malabsorption (FCM) is supported.
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TLDR
In this study of patients with megaloblastic anemia due to cobalamin deficiency, p.o. Cobalamin treatment was as effective as i.m. cobalamine treatment and better tolerated and less expensive compared with IM treatment.
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TLDR
The lowest dose of oral cyanocobalamin required to normalize mild vitamin B(12) deficiency is more than 200 times greater than the recommended dietary allowance, which is approximately 3 mug daily.
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TLDR
In cobalamin deficiency, 2 mg of cyanocobalamin administered orally on a daily basis was as effective as 1 mg administered intramuscularly on a monthly basis and may be superior.
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TLDR
The epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome, are reviewed, and diagnostic and management strategies for cobalamina deficiency are reviewed.
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TLDR
Mutations in genes encoding endocytic receptors involved in the ileal absorption and cellular uptake of cobalamin have been recently uncovered and explain, at least in part, the hereditary component of megaloblastic anemia.
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