Efficacy of oral calcium pentosan polysulphate for the treatment of osteoarthritis of the canine stifle joint secondary to cranial cruciate ligament deficiency

@article{Innes2000EfficacyOO,
  title={Efficacy of oral calcium pentosan polysulphate for the treatment of osteoarthritis of the canine stifle joint secondary to cranial cruciate ligament deficiency},
  author={John F. Innes and Alistair R S Barr and Mohammed Sharif},
  journal={Veterinary Record},
  year={2000},
  volume={146},
  pages={433 - 437}
}
The efficacy of calcium pentosan polysulphate (CaPPS) as a slow-acting drug for the treatment of osteoarthritis of the canine stifle joint, secondary to cranial cruciate ligament deficiency, was tested in a double-blind, placebo-controlled clinical trial over a period of one year. Dogs with the deficiency were treated surgically, matched for bodyweight, and randomly assigned to treatment or placebo groups. Active treatment began six weeks postoperatively and consisted of 10 mg/kg caPPs orally… 
Evaluation of pentosan polysulfate sodium in the postoperative recovery from cranial cruciate injury in dogs: a randomized, placebo-controlled clinical trial.
TLDR
PPS administered after stabilization of the cruciate deficient stifle may prove to be a useful adjunctive treatment option, although further studies are necessary to substantiate this claim.
Sulfato de condroitina e hialuronato de sódio no tratamento da doença articular degenerativa experimental em cães: aspectos clínicos e radiológicos
TLDR
The results demonstrated that the group treated with sodium hyaluronate had lower degree of lameness in comparison with other groups, probably due to the greater action of the drug in the synovium, decreasing the pain and lameness.
Randomised, double-blind, placebocontrolled parallel group study of P54FP for the treatment of dogs with osteoarthritis
TLDR
It was shown that there was no statistically significant difference between the groups in terms of the Pvz of the affected limb, and the investigators' overall assessment showed a statistically significant treatment effect in favour of P54FP, but the owners' assessment just failed to reach statistical significance.
Pentosan Polysulfate as a Disease Modifier of Cartilage Degeneration in Experimental Osteoarthritis
TLDR
NaPPS treatment significantly reduced synovial fluid Ca, Mg, P and cartilage damage and resulted in significant improvement in clinical signs and articular cartilage healing, and no adverse effects were detected confirming that NaPPS has disease-modifying properties.
Chondroprotectant therapy in rats with degenerative joint disease experimentally transected cranial cruciate
TLDR
Evaluated rats that were surgically induced to OA using two different drug therapies, pentosan polysulfate is recommendable for the treatment of iatrogenic joint lesions in rats since the other treatments showed no significant difference.
Systematic review of the management of canine osteoarthritis
TLDR
This review assesses the evidence for the efficacy of therapies used in the management of osteoarthritis in dogs on the basis of papers published in peerreviewed journals in English between 1985 and July 2007 to find a high level of comfort and a moderate level of Comfort for carprofen, firocoxib and meloxicam.
Use of client-specific outcome measures to assess treatment effects in geriatric, arthritic dogs: controlled clinical evaluation of a nutraceutical.
TLDR
Compared with the placebo group, the treatment response was significantly better in the SMPC group with regard to case-specific scores and owner global assessments, and the product was well tolerated and serum chemistry findings remained within normal limits.
Use of animal models of osteoarthritis in the evaluation of potential new therapeutic agents
TLDR
This chapter describes animal models of OA and focuses on their recent use in the evaluation of potential therapeutic modalities, hoping that this chapter will serve as a valuable reference to OA animal models and examples of their uses with various types of chemical and biological agents, and facilitate the design of studies to investigate new therapeutic agents.
Pharmacotherapy for Osteoarthritis: A Review
TLDR
Osteoarthritis is a leading cause of disability in the elderly and scientists are looking for new therapeutic targets like IL-1 receptor antagonist (IL-1Ra), mitogen-activated protein (MAP) kinases inhibitors, NF-kappaB inhibitors, which showed some promise in animal models.
...
1
2
3
4
...

References

SHOWING 1-10 OF 34 REFERENCES
Systemic use of pentosan polysulphate in the treatment of osteoarthritis.
TLDR
There were no differences between groups in baseline data, but dogs receiving PPS had a favourable response compared to dogs receiving a placebo for lameness, body condition, pain on joint manipulation and willingness to exercise.
Clinical natural history of the postsurgical cruciate deficient canine stifle joint: year 1.
The aims of this prospective study were to investigate the associations and correlations between individual clinical features of osteoarthritis of the cruciate deficient stifle joint and to document
Changes in concentrations of biochemical markers of osteoarthritis following surgical repair of ruptured cranial cruciate ligaments in dogs.
TLDR
Results support the hypothesis that serum concentration of 5D4 is not a useful marker of osteoarthritis in dogs, and transiently reduced the concentration of5D4 in synovial fluid but had no effect on S-GAG concentration.
Relations between biochemical markers of osteoarthritis and other disease parameters in a population of dogs with naturally acquired osteoarthritis of the genual joint.
TLDR
Serum 5D4 concentration is not a useful marker of stifle osteoarthritis in dogs; however, synovial fluid S-GAG and5D4 values may hold more promise as disease measures.
Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection.
TLDR
In adult foxhounds and mongrels knee instability did not lead to loss of cartilage but to an active synthetic response by the chondrocytes resulting in hypertrophic cartilage repair which was sustained for up to 64 weeks of observation.
Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection.
TLDR
In adult foxhounds and mongrels knee instability did not lead to loss of cartilage but to an active synthetic response by the chondrocytes resulting in hypertrophic cartilage repair which was sustained for up to 64 weeks of observation.
The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment.
  • P. Ghosh
  • Medicine
    Seminars in arthritis and rheumatism
  • 1999
TLDR
The data presented in this review support the contention that NaPPS and CaPPS should be classified as SMOADs, however, additional long-term clinical studies employing methods of assessing joint structural changes will be needed to confirm this view.
...
1
2
3
4
...