Efficacy of oleylphosphocholine (OlPC) in vitro and in a mouse model of invasive aspergillosis.

@article{Paulussen2015EfficacyOO,
  title={Efficacy of oleylphosphocholine (OlPC) in vitro and in a mouse model of invasive aspergillosis.},
  author={Caroline Paulussen and Ga{\"e}lle A V Boulet and Tom Bosschaerts and P. Merino de Cos and Anny Fortin and Louis Maes},
  journal={Mycoses},
  year={2015},
  volume={58 3},
  pages={127-32}
}
Invasive aspergillosis (IA) has become increasingly common and is characterised by high morbidity and mortality. Upcoming resistance threatens treatment with azoles and highlights the continuous need for novel therapeutics. This laboratory study investigated the in vitro and in vivo potential of the alkylphospholipid oleylphosphocholine (OlPC) against Aspergillus. In vitro activities of OlPC, miltefosine, posaconazole and voriconazole were determined for Aspergillus fumigatus, A. niger, A… CONTINUE READING