Efficacy of novel antimicrobials against clinical isolates of opportunistic amebas.

@article{Schuster1998EfficacyON,
  title={Efficacy of novel antimicrobials against clinical isolates of opportunistic amebas.},
  author={Forstassessor Ludwig Schuster and Govinda S. Visvesvara},
  journal={The Journal of eukaryotic microbiology},
  year={1998},
  volume={45 6},
  pages={612-8}
}
We examined the effects of the macrolide antimicrobial agent azithromycin and phenothiazine compounds against clinical isolates of Acanthamoeba spp. and Balamuthia mandrillaris, opportunistic pathogens of human beings and other animals. Acanthamoeba growth was inhibited in vitro at 1, 5, and 10 micrograms/ml of azithromycin, but not the macrolides, erythromycin, and clarithromycin. In experiments attempting to simulate in vivo conditions, azithromycin protected monolayers of rat glioma cells… CONTINUE READING
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