Efficacy of new 5-nitroimidazoles against metronidazole-susceptible and -resistant Giardia, Trichomonas, and Entamoeba spp.

@article{Upcroft1999EfficacyON,
  title={Efficacy of new 5-nitroimidazoles against metronidazole-susceptible and -resistant Giardia, Trichomonas, and Entamoeba spp.},
  author={J. A. Upcroft and Ronald W. F. Campbell and Kamel Benakli and P. Upcroft and Patrice Vanelle},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 1},
  pages={73-6}
}
The efficacies of 12 5-nitroimidazole compounds and 1 previously described lactam-substituted nitroimidazole with antiparasitic activity, synthesized via SRN1 and subsequent reactions, were assayed against the protozoan parasites Giardia duodenalis, Trichomonas vaginalis, and Entamoeba histolytica. Two metronidazole-sensitive lines and two metronidazole-resistant lines of Giardia and one line each of metronidazole-sensitive and -resistant Trichomonas were tested. All except one of the compounds… CONTINUE READING

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