Efficacy of miltefosine for the treatment of American cutaneous leishmaniasis.

  title={Efficacy of miltefosine for the treatment of American cutaneous leishmaniasis.},
  author={Iv{\'a}n Dar{\'i}o V{\'e}lez and Liliana L{\'o}pez and Ximena Sanchez and Laureano Mestra and C. Perez Rojas and Erwin Rodr{\'i}guez},
  journal={The American journal of tropical medicine and hygiene},
  volume={83 2},
Miltefosine is an oral agent used for cutaneous leishmaniasis treatment. An open-label, randomized, phase III clinical trial was carried out in the Colombian army population. Miltefosine, 50 mg capsule was taken orally three times per day for 28 days (N = 145) or meglumine antimoniate, 20 mg/kg body weight per day for 20 days by intramuscular injection (N = 143). The efficacy of miltefosine by protocol was 69.8% (85/122 patients) and 58.6% (85/145 patients) by intention to treat. For meglumine… CONTINUE READING
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