Efficacy of methotrexate in ulcerative colitis: failure or promise.

  title={Efficacy of methotrexate in ulcerative colitis: failure or promise.},
  author={Hans H. Herfarth and Mark T Osterman and Kim L. Isaacs and James D Lewis and Bruce E Sands},
  journal={Inflammatory bowel diseases},
  volume={16 8},
BACKGROUND Low-dose methotrexate is a widely used and efficacious therapy in chronic inflammatory disorders such as psoriasis and rheumatoid arthritis. Prospective randomized controlled trials have demonstrated the efficacy of parenteral methotrexate in Crohn's disease (CD). We performed a systematic review of the efficacy of methotrexate in ulcerative colitis (UC) and discuss the results in the context of the known pharmacokinetics and adverse events of methotrexate therapy in inflammatory… CONTINUE READING
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