Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis

@article{Persi1997EfficacyOM,
  title={Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis},
  author={Lauren N. Persi and O Dupin and B. Arnaud and Claude Trinquand and F. B. Michel and Jean Bousquet},
  journal={Allergy},
  year={1997},
  volume={52}
}
Pharmacologic intervention in the management of allergic conjunctivitis was evaluated with different topical ocular agents in man. Their effect can be precisely assessed with the conjunctival provocation test (CPT). A potent specific H1‐receptor antagonist, 0.05% mequitazine eye‐drops, was tested in a double‐blind, randomized, placebo‐controlled study using CPT with grass pollen allergens. Twenty healthy subjects allergic to grass pollen were included outside the pollen season after a positive… 

A Comparison of Topical Mequitazine and Disodium Cromoglycate in Allergic Conjunctivitis Induced by a Specific Conjunctival Provocation Test

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These results demonstrate the superior efficacy of a single drop of 0.05% mequitazine 15 min before CPT compared with 2% disodium cromoglycate 4 times daily for 4 days.

Randomised double masked trial comparing the efficacy and tolerance of 0.05% mequitazine eye drops versus 0.05% levocabastine and placebo in allergic conjunctivitis induced by a conjunctival provocation test with Dermatophagoides pteronyssinus

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This trial failed to clearly demonstrate curative superiority of topical antihistamines with placebo, when a single dose of treatment was instilled following Conjunctival provocation tests, however mequitazine 0.05% eye drops were superior to placebo in preventing a reaction to CPT, after 2 weeks of treatment.

RONDE DE LA SFO « ALLERGIES EN OPHTALMOLOGIE » Les tests de provocation conjonctivaux

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