Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis

  title={Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis},
  author={Lauren N. Persi and O Dupin and B. Arnaud and Claude Trinquand and F. B. Michel and Jean Bousquet},
Pharmacologic intervention in the management of allergic conjunctivitis was evaluated with different topical ocular agents in man. Their effect can be precisely assessed with the conjunctival provocation test (CPT). A potent specific H1‐receptor antagonist, 0.05% mequitazine eye‐drops, was tested in a double‐blind, randomized, placebo‐controlled study using CPT with grass pollen allergens. Twenty healthy subjects allergic to grass pollen were included outside the pollen season after a positive… 

A Comparison of Topical Mequitazine and Disodium Cromoglycate in Allergic Conjunctivitis Induced by a Specific Conjunctival Provocation Test

These results demonstrate the superior efficacy of a single drop of 0.05% mequitazine 15 min before CPT compared with 2% disodium cromoglycate 4 times daily for 4 days.

Randomised double masked trial comparing the efficacy and tolerance of 0.05% mequitazine eye drops versus 0.05% levocabastine and placebo in allergic conjunctivitis induced by a conjunctival provocation test with Dermatophagoides pteronyssinus

This trial failed to clearly demonstrate curative superiority of topical antihistamines with placebo, when a single dose of treatment was instilled following Conjunctival provocation tests, however mequitazine 0.05% eye drops were superior to placebo in preventing a reaction to CPT, after 2 weeks of treatment.

RONDE DE LA SFO « ALLERGIES EN OPHTALMOLOGIE » Les tests de provocation conjonctivaux

The conjunctival provocation test (CPT) is a human model of ocular allergy that has been used to study the ocular response to allergenic stimuli and to evaluate antiallergic therapy. Considerable


It is suggested that patients who have received IT for at least two years can safety restart their treatment if they happen to discontinue it with smaller than the recommended reductions utilizing the maintenance concentration.

Allergic rhinitis and its impact on asthma.

This systematic review and meta-analyses confirmed the findings of a previous study published in “Rhinitis and Asthma: Causes and Prevention, 2nd Ed.” (2015) as well as new findings of “Mechanisms of Respiratory Disease and Allergology,” which confirmed the role of EMTs in the development of these diseases.

Therapeutic management of allergic diseases

The aim of this chapter was to describe succinctly the modes of action, indications, and side effects of the major antiallergic and antiasthmatic drugs.

Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate.

A short and straightforward synthesis of the antihistaminic drug mequitazine is reported, based on an efficient palladium catalyzed allylic alkylation of 1-aza-bicyclo[2.2.2]oct-2-en-3-ylmethyl

Asymmetric synthesis of (+)-mequitazine from quinine.

The first asymmetric synthesis of the antihistaminic drug mequitazine is reported. Our approach started from quinine, a Cinchona alkaloid, whose chiral information was exploited for setting up the



Conjunctival allergen challenge. A clinical approach to studying allergic conjunctivitis.

Five allergen challenge studies of increasing refinement suggested that ocular challenge was highly correlated with skin reactivity and reproducible with a second challenge, and no statistically significant difference in redness and itching was found when both eyes were challenged with the same dose of allerGEN.

Protective effect of loratadine on specific conjunctival provocation test.

Loratadine exerts a significant protective effect on the early phase cellular and clinical events of conjunctival reaction induced by allergen challenge in atopic patients.

Precision of conjunctival provocation tests in right and left eyes.

Inflammatory mediator release on conjunctival provocation of allergic subjects with allergen.

A Double-Blind Comparison of Terfenadine and Mequitazine in the Symptomatic Treatment of Acute Pollinosis

In conclusion terfenadine and mequitazine displayed the same efficacy for symptoms of pollinosis, but terfenadinie was better tolerated.

Levocabastine Eye Drops: A New Approach for the Treatment of Acute Allergic Conjunctivitis

Acute allergic conjunctivitis (AAC) is a common ocular allergic disorder and incident rates as high as 20% have been reported. Although a wide range of therapeutic agents are available for the

Drug treatment of allergic conjunctivitis. A review of the evidence.

Allergic conjunctivitis, unlike several other ocular diseases, is seldom followed by permanent visual impairment; nevertheless, it is important because of both its frequency and its severity. Two

The Precision of the Conjunctival Provocation Test

It is concluded that CPT is useful in clinical research when indicated in clinical routine and is a sale and easy test with good precision.

Mequitazine and dexchlorpheniramine in perennial rhinitis. A double-blind cross-over placebo-controlled study.

In controlling perennial rhinitis symptoms mequitazine was markedly inferior to dexchlorpheniramine and only slightly better than placebo, and 20 out of 29 patients chose dexchlor pheniramine as their favourite drug.