Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis

  title={Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis},
  author={Lauren N. Persi and O Dupin and B. Arnaud and Claude Trinquand and F. B. Michel and Jean Bousquet},
Pharmacologic intervention in the management of allergic conjunctivitis was evaluated with different topical ocular agents in man. Their effect can be precisely assessed with the conjunctival provocation test (CPT). A potent specific H1‐receptor antagonist, 0.05% mequitazine eye‐drops, was tested in a double‐blind, randomized, placebo‐controlled study using CPT with grass pollen allergens. Twenty healthy subjects allergic to grass pollen were included outside the pollen season after a positive… 
A Comparison of Topical Mequitazine and Disodium Cromoglycate in Allergic Conjunctivitis Induced by a Specific Conjunctival Provocation Test
These results demonstrate the superior efficacy of a single drop of 0.05% mequitazine 15 min before CPT compared with 2% disodium cromoglycate 4 times daily for 4 days.
Randomised double masked trial comparing the efficacy and tolerance of 0.05% mequitazine eye drops versus 0.05% levocabastine and placebo in allergic conjunctivitis induced by a conjunctival provocation test with Dermatophagoides pteronyssinus
This trial failed to clearly demonstrate curative superiority of topical antihistamines with placebo, when a single dose of treatment was instilled following Conjunctival provocation tests, however mequitazine 0.05% eye drops were superior to placebo in preventing a reaction to CPT, after 2 weeks of treatment.
RONDE DE LA SFO « ALLERGIES EN OPHTALMOLOGIE » Les tests de provocation conjonctivaux
The conjunctival provocation test (CPT) is a human model of ocular allergy that has been used to study the ocular response to allergenic stimuli and to evaluate antiallergic therapy. Considerable
Allergic rhinitis and its impact on asthma.
This systematic review and meta-analyses confirmed the findings of a previous study published in “Rhinitis and Asthma: Causes and Prevention, 2nd Ed.” (2015) as well as new findings of “Mechanisms of Respiratory Disease and Allergology,” which confirmed the role of EMTs in the development of these diseases.
Therapeutic management of allergic diseases
The aim of this chapter was to describe succinctly the modes of action, indications, and side effects of the major antiallergic and antiasthmatic drugs.
Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate.
A short and straightforward synthesis of the antihistaminic drug mequitazine is reported, based on an efficient palladium catalyzed allylic alkylation of 1-aza-bicyclo[2.2.2]oct-2-en-3-ylmethyl
Asymmetric synthesis of (+)-mequitazine from quinine.
The first asymmetric synthesis of the antihistaminic drug mequitazine is reported. Our approach started from quinine, a Cinchona alkaloid, whose chiral information was exploited for setting up the
Topical immunopharmacology of ocular allergies
A number of available drugs and natural non-prescription agents may have anti-histaminic and anti-inflammatory actions.


Protective effect of loratadine on specific conjunctival provocation test.
Loratadine exerts a significant protective effect on the early phase cellular and clinical events of conjunctival reaction induced by allergen challenge in atopic patients.
Inflammatory mediator release on conjunctival provocation of allergic subjects with allergen.
Levocabastine Eye Drops: A New Approach for the Treatment of Acute Allergic Conjunctivitis
Acute allergic conjunctivitis (AAC) is a common ocular allergic disorder and incident rates as high as 20% have been reported. Although a wide range of therapeutic agents are available for the
Drug treatment of allergic conjunctivitis. A review of the evidence.
Allergic conjunctivitis, unlike several other ocular diseases, is seldom followed by permanent visual impairment; nevertheless, it is important because of both its frequency and its severity. Two
The Precision of the Conjunctival Provocation Test
It is concluded that CPT is useful in clinical research when indicated in clinical routine and is a sale and easy test with good precision.
Mequitazine and dexchlorpheniramine in perennial rhinitis. A double-blind cross-over placebo-controlled study.
In controlling perennial rhinitis symptoms mequitazine was markedly inferior to dexchlorpheniramine and only slightly better than placebo, and 20 out of 29 patients chose dexchlor pheniramine as their favourite drug.
Serum eosinophil cationic protein during treatment of asthma in children.
The H1-antagonist mequitazine: Studies on performance and visual function
Mequitazine (5 mg) and terfenadine (60 mg) are likely to prove acceptable H1 antagonists when sedation must be avoided.
Studies with different types of visual analog scales for measurement of pain
It is concluded that graded linear horizontal scales are both more reliable and preferred by participants and that visual analog scales give a more sensitive and accurate representation of pain intensity than do descriptive pain scales.