Efficacy of mGlu2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures.

Abstract

OBJECTIVE The metabotropic glutamate receptor subtype 2 (mGlu2 ) possesses both orthosteric and allosteric modulatory sites, are expressed in the frontal cortex and limbic structures, and can affect excitatory synaptic transmission. Therefore, mGlu2 is a potential therapeutic target in the treatment of epilepsy. The present study seeks to evaluate the… (More)
DOI: 10.1111/epi.13659

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@article{Metcalf2017EfficacyOM, title={Efficacy of mGlu2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures.}, author={Cameron S. Metcalf and Brian D. Klein and Misty D. Smith and Tim Pruess and Marc Ceusters and Hilde Lavreysen and Stefan Pype and Nancy van Osselaer and Roy E. Twyman and H. Steve White}, journal={Epilepsia}, year={2017}, volume={58 3}, pages={484-493} }